Seroprevalence of Toxoplasma gondii Infection Among Β-Thalassemia Major Pediatric Population: Implications for Transfusion Transmissible Toxoplasmosis

The Pediatric Infectious Disease Journal
Nora L El-TantawyEman Eissa

Abstract

Children with β-thalassemia major who regularly receive blood transfusion are at risk of developing transfusion-transmitted infection. Toxoplasmosis is a common and a serious parasitic disease with high prevalence and could be transmitted through blood transfusion from healthy asymptomatic donors. However, screening Toxoplasma gondii before blood donation has not been considered. The objective of this study was to determine the prevalence of T. gondii antibodies among thalassemia children undergoing blood transfusion. In a case-control study, serum samples from 211 thalassemia children and 100 control children were investigated for Toxoplasma IgM and IgG using the enzyme-linked immunosorbent assay. Positive serum samples for IgG antibodies to T. gondii were further subjected to IgG avidity enzyme-linked immunosorbent assay. The seroprevalence of Toxoplasma infection among thalassemia children was 23.2% and 53.6% for IgM and IgG anti-Toxoplasma antibodies, respectively. Whereas in the control group, the prevalence was 5% and 18% for IgM and IgG anti-Toxoplasma antibodies, respectively. There is a significant statistical difference between thalassemia and control groups regarding the prevalence of toxoplasmosis. From these positi...Continue Reading

References

Feb 28, 2002·The Journal of Infectious Diseases·Jose G Montoya
Jul 8, 2005·Journal of Clinical Microbiology·Cynthia PressJack S Remington
Jul 17, 2007·BMC Infectious Diseases·Cosme Alvarado-EsquivelSergio Arturo Martínez-García
Dec 12, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P FloriR Tran Manh Sung
Jun 10, 2008·Indian Journal of Pediatrics·Richa JainAshok K Deorari
Dec 17, 2009·Hemoglobin·Amal El-Beshlawy, Ilham Youssry
Jul 8, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Priti ElhenceRajendra K Chaudhary
May 17, 2011·Middle East African Journal of Ophthalmology·Huda Al-GhadeerArif O Khan
Apr 12, 2012·Clinical Microbiology Reviews·Florence Robert-Gangneux, Marie-Laure Dardé
Jul 9, 2013·Handbook of Clinical Neurology·Sandra K Halonen, Louis M Weiss
May 9, 2014·The American Journal of Tropical Medicine and Hygiene·Jeffrey L JonesAnthony E Fiore
May 6, 2016·Transfusion Medicine Reviews·Masoud Foroutan-RadEhsan Ahmadpour
Mar 21, 2017·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·J SakiR Abdizadeh

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Citations

Apr 14, 2019·Journal of Viral Hepatitis·Giuseppe IndolfiUNKNOWN PENTAHep Study Group
Jan 30, 2020·Frontiers in Cellular and Infection Microbiology·Fabiana NakashimaLuiz Carlos de Mattos

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