Seroprevalence of trichodysplasia spinulosa-associated polyomavirus in Japan

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Hitomi FukumotoHarutaka Katano

Abstract

Trichodysplasia spinulosa-associated polyomavirus (TSV) was identified in, and shown to be the probable cause of, trichodysplasia spinulosa, a rare skin disease. To date, serological analyses have revealed that TSV infection is common among adults in the general population of Europe and Australia. However, there have been no reports of TSV in Asia. To study the prevalence of TSV infection in Japan. TSV-VP1 expressed in a recombinant baculovirus expression system in an insect cell line, Tn5, self-assembled into virus-like particles. Overall, 1000 serum samples were examined by enzyme-linked immunosorbent assays using virus-like particles of TSV as antigen. Participants ranged in age from 0 to 94 years. Overall, 629 of 1000 serum samples (62.9%) were positive for anti-TSV antibodies. The seropositive rate increased with age and the seroprevalence of TSV significantly increased from 17.1% (25/146) in children aged from 0 to 4 years to 78.7% (472/600) in adults aged over 20 years (odds ratio = 0.056, 95% confidence interval = 0.035-0.900, P = 0.000, Chi-squared test). TSV seropositivity was not different between sera obtained in 1980 and 2012, and was not associated with sex. Competitive assay demonstrated that TSV antibodies did n...Continue Reading

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Citations

Nov 26, 2015·Diagnostic Microbiology and Infectious Disease·Paulo R UrbanoCamila M Romano
Oct 20, 2015·The British Journal of Dermatology·J H WuS K Tyring
Dec 17, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Paulo Roberto UrbanoCamila Malta Romano
Mar 28, 2019·Pediatric Transplantation·Hope BaroneTracy Funk
Aug 5, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Deepika NarayananStephen K Tyring
Dec 4, 2019·Japanese Journal of Infectious Diseases·Toshie NakoHarutaka Katano
Feb 10, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·P CurmanH Brauner

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