Serosorting and HIV/STI Infection among HIV-Negative MSM and Transgender People: A Systematic Review and Meta-Analysis to Inform WHO Guidelines

Journal of Sexually Transmitted Diseases
Caitlin KennedyKevin O'Reilly

Abstract

We conducted a systematic review and meta-analysis to assess the association between serosorting and HIV infection, sexually transmitted infections (STIs), and quality of life among men who have sex with men (MSM) and transgender people. Two reviewers independently screened abstracts and abstracted data. Meta-analyses were conducted using random effects models. Of 310 citations reviewed, 4 observational studies, all with MSM, met inclusion criteria. Compared to consistent condom use, serosorting was associated with increased risk of HIV (3 studies, odds ratio (OR): 1.80, 95% confidence interval (CI):1.21-2.70) and bacterial STIs (1 study, OR: 1.62, 95% CI: 1.44-1.83). Compared to no condom use, serosorting was associated with reduced risk of HIV (3 studies, OR: 0.46, 95% CI: 0.25-0.83) and bacterial STIs (1 study, OR: 0.81, 95% CI: 0.73-0.91). Among HIV-negative MSM, condom use appears to be more protective against HIV and STIs than serosorting and should be encouraged. However, serosorting may be better than no condom use as a harm reduction strategy.

References

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Citations

Feb 20, 2020·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Darrel H HigaUNKNOWN Prevention Research Synthesis (PRS) Project
Feb 12, 2014·Archives of Virology·Ahmed S Abdel-Moneim
May 9, 2015·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·R MalekG Hughes
Nov 5, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Klaus JansenUlrich Marcus
Apr 22, 2017·JMIR Public Health and Surveillance·Joyal Miranda, José Côté
Jan 23, 2018·American Journal of Men's Health·John ShaverRob Stephenson
Apr 19, 2018·Current Infectious Disease Reports·Christine L Heumann

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Software Mentioned

Comprehensive Meta - Analysis
EndNote
GRADE

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