Serotonergic activation of locomotor behavior and posture in one-day old rats

Behavioural Brain Research
Hillary E SwannMichele R Brumley

Abstract

The purpose of this study was to determine what dose of quipazine, a serotonergic agonist, facilitates air-stepping and induces postural control and patterns of locomotion in newborn rats. Subjects in both experiments were 1-day-old rat pups. In Experiment 1, pups were restrained and tested for air-stepping in a 35-min test session. Immediately following a 5-min baseline, pups were treated with quipazine (1.0, 3.0, or 10.0 mg/kg) or saline (vehicle control), administered intraperitoneally in a 50 μL injection. Bilateral alternating stepping occurred most frequently following treatment with 10.0 mg/kg quipazine, however the percentage of alternating steps, interlimb phase, and step period were very similar between the 3.0 and 10.0 mg/kg doses. For interlimb phase, the forelimbs and hindlimbs maintained a near perfect anti-phase pattern of coordination, with step period averaging about 1s. In Experiment 2, pups were treated with 3.0 or 10.0 mg/kg quipazine or saline, and then were placed on a surface (open field, unrestrained). Both doses of quipazine resulted in developmentally advanced postural control and locomotor patterns, including head elevation, postural stances, pivoting, crawling, and a few instances of quadrupedal walk...Continue Reading

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Mar 6, 2015·Developmental Psychobiology·Michele R BrumleyHillary E Swann
Mar 19, 2015·Developmental Psychobiology·Caroline TeulierBeverly D Ulrich

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Citations

Jun 21, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Ana Leticia Coronado DorceAna Leonor Abrahão Nencioni
Feb 18, 2021·Behavioural Pharmacology·Hillary E Swann-ThomsenMichele R Brumley
Aug 20, 2021·The Journal of Physiology·Marie BoulainLaurent Juvin

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