Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent

Experimental Neurology
Marc CuestaEtienne Challet

Abstract

The main circadian clock, localized in the suprachiasmatic nuclei (SCN) in mammals, can be synchronized by light and non-photic factors such as serotonergic cues. In nocturnal rodents, injections during the subjective day of the 5-HT1A/7 receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) or its positive enantiomer, induce behavioral phase-advances in correlation with decreased expression of two clock genes, Per1/2. In addition, 8-OH-DPAT and the selective serotonin reuptake inhibitor fluoxetine reduce light-induced phase-shifts during the subjective night. Beside the chronobiotic effects of serotonin, changes of serotonergic activity in humans have been involved in mood disorders, that are often associated with alterations in circadian rhythmicity. To get insights into the circadian role of serotonin in diurnal species, we investigated its modulation of the SCN in Arvicanthis ansorgei housed in constant darkness. In striking contrast to nocturnal rodents, daily serotonin content in Arvicanthis SCN peaked during daytime while the sensitivity window of its SCN to (+)8-OH-DPAT occurred essentially during the subjective night. Moreover, fluoxetine produced behavioral phase-advances at circadian time (CT) 0 and CT1...Continue Reading

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Citations

Jun 2, 2012·Journal of Neural Transmission·Harris Eyre, Bernhard T Baune
Dec 20, 2013·Journal of Neural Transmission·Tal Ashkenazy-FrolingerNoga Kronfeld-Schor
Oct 15, 2013·Trends in Pharmacological Sciences·Analyne M Schroeder, Christopher S Colwell
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May 10, 2012·The Journal of Physiology·Jorge MendozaEtienne Challet
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May 22, 2009·Journal of Neurochemistry·Marc CuestaEtienne Challet
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Jan 14, 2021·Neuroscience and Biobehavioral Reviews·Pawan Kumar JhaEtienne Challet
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care

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