PMID: 6172060Dec 1, 1981Paper

Serotonergic activity in man as a function of pain, pain mechanisms, and depression

Anesthesia and Analgesia
J N GhiaW Mao

Abstract

Lumbar cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, which are used as indicators of central nervous system serotonergic neuronal activity, were significantly higher in 67 patients with chronic pain and in 32 patients with acute pain (23.6 +/- 3.3 and 23.1 +/- 3.8, respectively) than in 30 patients (8.8 +/- 1.7) who had no pain. However, there was no correlation between levels of 5-hydroxyindoleacetic acid in patients with chronic or acute pain, nor between groups of patients with chronic pain whose pain mechanisms were of psychogenic, sympathetic, somatic, or central origin, based on their responses to differential spinal block; there was also no correlation between levels of depression, as evaluated by the Zung scale, in patients with different types of chronic pain, even though all of these patients were depressed. The elevated levels of 5-hydroxyindoleacetic acid in the depressed patients with chronic pain are not consistent with previous studies on the etiology and types of chronic pain. As recent research indicates that the perception of pain may be modulated by endogenous analgesic systems involving enkephalin and serotonin (5-HT), this study was undertaken to clarify the association between 5-HT activity and...Continue Reading

Citations

Apr 1, 1989·The Journal of the American Dental Association·J W StockstillB Piniewski
Feb 11, 2015·The Journal of Pain : Official Journal of the American Pain Society·Alexandre J ParentPhilippe Goffaux
Nov 1, 1987·Pain·R D FranceC B Nemeroff

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