Serotonergic activity measured by platelet [3H]paroxetine binding in patients with eating disorders

Psychiatry Research
Carla E RamacciottiLiliana Dell'Osso

Abstract

Most of the evidence from pharmacological studies supports the hypothesis of a serotonergic (5-HT) dysregulation in eating disorders (ED), though a specific alteration related to the major ED subtypes, anorexia (AN) and bulimia nervosa (BN), has not been identified yet, possibly because of changes over time in ED nosology. The aim of the present study was to verify whether differences in serotonergic activity, measured by platelet [3H]paroxetine binding, would validate current ED classification. Platelet [3H]paroxetine binding was investigated in 26 patients with eating disorders diagnosed in accord with DSM-IV criteria (AN, n=11; BN, n=15) and 26 normal weight controls of comparable age; ED symptomatology was assessed by the Diagnostic Schedule for Eating Disorders. ED patients had significantly lower B(max) values than controls (288.5+/-109.2 vs. 1396.8+/-251.3 fmol/mg), whereas the K(d) was not significantly altered (0.12+/-0.13 and 0.12+/-0.05 nM, respectively). Among patients, differences in B(max) were related neither to DSM-IV subtypes nor to clinical variables such as presence of binge-eating, purging, impulsive behaviors, or symptoms of depression. Although ED patients share a dysregulation in serotonergic activity, DS...Continue Reading

References

Oct 1, 1979·European Journal of Pharmacology·M S BrileyS Z Langer
Dec 1, 1991·Acta Psychiatrica Scandinavica·F Hassanyeh, E F Marshall
Jan 1, 1990·Drugs·S F Leibowitz
Jan 1, 1988·Life Sciences·D MarazzitiG B Cassano
Jan 1, 1985·Journal of Psychiatric Research·P Slade
Dec 23, 1983·European Journal of Pharmacology·E T MellerupM Engelstoft
Oct 1, 1980·The Journal of Nervous and Mental Disease·C Treece, B Nicholson
Nov 1, 1996·Psychological Medicine·P J CowenC G Fairburn
Jan 1, 1996·Neuropsychobiology·D MarazzitiG B Cassano
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·O SpigsetT Mjöndal
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Feb 9, 2011·BMC Neuroscience·Gino GiannacciniAntonio Lucacchini
Oct 22, 2013·BMC Neuroscience·Gino GiannacciniAntonio Lucacchini
Dec 31, 2009·Neurochemical Research·Gino GiannacciniAntonio Lucacchini
Feb 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jennifer A Bartz, Eric Hollander
Jan 31, 2013·The International Journal of Neuroscience·Jeanette SigurdhBruno Hägglöf
Jul 20, 2005·Annals of Medicine·Nadine Norton, Michael J Owen
Jul 7, 2015·CNS Spectrums·Mario MiniatiLiliana Dell'Osso
Mar 18, 2019·Psychiatry Research·Magnus SjögrenJitka Stilund Hansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.