Serotonergic cell signaling in an animal model of aging and depression: olfactory bulbectomy elicits different adaptations in brain regions of young adult vs aging rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Theodore A SlotkinFrederic J Seidler

Abstract

Aging involves neuronal and synaptic loss, and maintenance of function depends on adaptations in cellular responsiveness. We studied olfactory bulbectomy (OBX), a model that recapitulates monoaminergic dysfunction in depression, in 10-week vs 19-month-old rats, and evaluated 5HT (5-hydroxytryptamine, serotonin) mechanisms. OBX elicited little change in 5HT1A receptors in the cerebral cortex or striatum of either age group. In contrast, 5HT2 receptors showed disparate effects, with a decrease in the cerebral cortex of young OBX but not aging OBX rats, whereas the latter group showed a selective decrease in striatal 5HT2 receptors. Greater differences were apparent for 5HT-mediated cell signaling, assessed for the adenylyl cyclase (AC) cascade. In young animals, 5HT had a stimulatory effect on AC that was unaltered by OBX. However, in aging animals, the pattern of 5HT responses showed marked alterations in response to OBX: under basal conditions, stimulatory effects were enhanced but when AC was activated with forskolin, 5HT became markedly inhibitory in the striatum of aged OBX animals. Assessment of the relative AC responses to two direct stimulants that act on different epitopes of the enzyme, forskolin and Mn2+, pointed to a ...Continue Reading

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Citations

Mar 28, 2008·Genes, Brain, and Behavior·L UrigüenJ J Meana
Jan 30, 2014·Longevity & Healthspan·Marije Oostindjer, Gro V Amdam
Mar 5, 2008·Biogerontology·Anita Jagota, D Kalyani
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Jan 10, 2009·Brain Research Bulletin·Boubacar Pasto WannGuy Rousseau
Sep 16, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M E BreuerB Olivier
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Jan 8, 2011·Neurochemistry International·Ivan SkelinMirko Diksic
Mar 24, 2018·Brain and Behavior·Taciani de Almeida MagalhãesAna Lúcia Brunialti Godard

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