Abstract
Sleep disturbances are common non-motor symptoms in Parkinson's disease (PD). Experimental studies suggest involvement of the serotonergic system in the regulation of sleep and arousal. Using [11C]DASB positron emission tomography, a marker of serotonin transporter availability, we investigated whether sleep dysfunction is associated with serotonergic dysfunction in PD. We studied 14 PD patients with sleep dysfunction, 14 PD without sleep dysfunction, and 12 healthy controls. Groups were matched for age, disease duration, severity of motor symptoms, daily intake of levodopa equivalent units, body-mass-index, depression and fatigue. [11C]DASB non-displaceable binding potential (BPND) was calculated for regions with a role in the regulation of sleep and arousal. [11C]DASB BPND was reduced by 32-49% in PD patients with sleep dysfunction, and 14-25% in PD without sleep dysfunction, compared to healthy controls. PD patients with sleep dysfunction had lower [11C]DASB BPND in caudate (P < 0.01), putamen (P < 0.001), ventral striatum (P < 0.001), thalamus (P < 0.05), hypothalamus (P < 0.001) and raphe nuclei (P < 0.01), compared to PD without sleep dysfunction. Higher severity of sleep symptoms (assessed with Parkinson Disease Sleep Sc...Continue Reading
Citations
Aug 5, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Connie MarrasTiago A Mestre
Oct 17, 2018·Frontiers in Neurology·Tayyabah YousafMarios Politis
Dec 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sang-Won YooJoong-Seok Kim
Feb 6, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Patrik FazioAndrea Varrone
Jul 8, 2020·Annals of Nuclear Medicine·Yujing ZhouXingdang Liu
Aug 4, 2018·Proteomes·Marcia RoySeth G N Grant
Jan 1, 2019·Journal of Chemical Neuroanatomy·Pollyana C LealJosé R Santos
Oct 27, 2020·Journal of Parkinson's Disease·Anna SauerbierK Ray Chaudhuri
Dec 6, 2020·Cells·Heather WilsonLefkos T Middleton
Feb 23, 2021·Frontiers in Neuroscience·Yanyan ZhangTian Tian
Mar 20, 2021·Frontiers in Neurology·Alham Al-SharmanKhalid El-Salem
Apr 27, 2021·Journal of Parkinson's Disease·Keisuke Suzuki
Jul 14, 2021·Scientific Reports·Jan-Paul GrassWilfried Dathe
Dec 23, 2021·PloS One·Sasivimol VirameteekulRoongroj Bhidayasiri
Jan 14, 2022·Experimental Neurology·Aviv D Mizrahi-KligerHagai Bergman