Serotonergic dysregulation is linked to sleep problems in Parkinson's disease

NeuroImage. Clinical
Heather WilsonMarios Politis

Abstract

Sleep disturbances are common non-motor symptoms in Parkinson's disease (PD). Experimental studies suggest involvement of the serotonergic system in the regulation of sleep and arousal. Using [11C]DASB positron emission tomography, a marker of serotonin transporter availability, we investigated whether sleep dysfunction is associated with serotonergic dysfunction in PD. We studied 14 PD patients with sleep dysfunction, 14 PD without sleep dysfunction, and 12 healthy controls. Groups were matched for age, disease duration, severity of motor symptoms, daily intake of levodopa equivalent units, body-mass-index, depression and fatigue. [11C]DASB non-displaceable binding potential (BPND) was calculated for regions with a role in the regulation of sleep and arousal. [11C]DASB BPND was reduced by 32-49% in PD patients with sleep dysfunction, and 14-25% in PD without sleep dysfunction, compared to healthy controls. PD patients with sleep dysfunction had lower [11C]DASB BPND in caudate (P < 0.01), putamen (P < 0.001), ventral striatum (P < 0.001), thalamus (P < 0.05), hypothalamus (P < 0.001) and raphe nuclei (P < 0.01), compared to PD without sleep dysfunction. Higher severity of sleep symptoms (assessed with Parkinson Disease Sleep Sc...Continue Reading

Citations

Aug 5, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Connie MarrasTiago A Mestre
Oct 17, 2018·Frontiers in Neurology·Tayyabah YousafMarios Politis
Dec 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sang-Won YooJoong-Seok Kim
Feb 6, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Patrik FazioAndrea Varrone
Aug 4, 2018·Proteomes·Marcia RoySeth G N Grant
Jan 1, 2019·Journal of Chemical Neuroanatomy·Pollyana C LealJosé R Santos
Feb 23, 2021·Frontiers in Neuroscience·Yanyan ZhangTian Tian
Dec 23, 2021·PloS One·Sasivimol VirameteekulRoongroj Bhidayasiri
Jan 14, 2022·Experimental Neurology·Aviv D Mizrahi-KligerHagai Bergman

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Methods Mentioned

BETA
MDS

Software Mentioned

SPSS
GraphPad Prism
statistical parametric mapping ( SPM )
ANALYZE

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