Sep 1, 2011

Serotonergic function and treatment of behavioral and psychological symptoms of frontotemporal dementia

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Nathan HerrmannKrista L Lanctôt


The purposes of this study were first, to evaluate the effectiveness of citalopram in treating behavioral disturbances in frontotemporal dementia (FTD) subjects and second, to determine whether an association exists between serotonergic function, as determined by a neuroendocrine challenge, and treatment response. Single-dose citalopram (30 mg per os) challenge followed by a 6-week open-label study. Outpatients referred to memory clinics. Fifteen patients suffering from FTD with severe behavioral and psychological symptoms of dementia. Following citalopram challenge, all patients were treated with citalopram titrated to a target dose of 40 mg once daily. Behavioral disturbances, using the Neuropsychiatric Inventory (NPI) (primary outcome) and Frontal Behavioural Inventory (secondary outcome), were assessed. Change in prolactin concentration following citalopram challenge was used as an index of central serotonergic response. Citalopram treatment was effective in treating behavioral symptoms, with significant decreases in NPI total score (F[2, 28] = 6.644, p = 0.004), disinhibition (F[2, 28] = 4.030, p = 0.029), irritability (F[2, 28] = 7.497, p = 0.003) and depression (F[2, 28] = 3.467, p = 0.045) scores over the 6 weeks. Signi...Continue Reading

  • References26
  • Citations30


  • References26
  • Citations30

Mentioned in this Paper

Mini-mental State Examination
Serotonin Reuptake Inhibitor [EPC]
Behavioral Symptoms
Severity of Illness Index
Adverse Event
PRL gene
Physiologic Disinhibition

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