PMID: 6978168Feb 1, 1982Paper

Serotonergic innervation of the lateral hypothalamus: evidence from synaptosomal uptake studies

Brain Research Bulletin
J Heym, W E Gladfelter

Abstract

Uptake of tritiated serotonin by synaptosomes prepared from rat lateral hypothalamus was examined. Uptake of serotonin into lateral hypothalamic synaptosomes occurred by both saturable and non-saturable processes. The saturable process was a high affinity transport with kinetic parameters that agree closely with those previously reported for serotonin uptake into synaptosomes prepared from other brain regions. Fluoxetine, a selective inhibitor of uptake into serotonergic neurons, was a potent inhibitor of serotonin uptake into lateral hypothalamic synaptosomes. Desipramine and benztropine, noradrenergic and dopaminergic uptake inhibitors respectively, were much less effective. Damage to the ascending serotonergic system, by either electrolytic lesion of the dorsal or median raphe nucleus, or by 5,7 dihydroxytryptamine injections into the midbrain serotonergic pathways, significantly reduced the uptake of serotonin by lateral hypothalamic synaptosomes. Taken together, these data provide further evidence for a serotonergic terminal field within the lateral hypothalamus.

References

Aug 1, 1978·The Journal of Comparative Neurology·R Y MooreB E Jones
Apr 7, 1977·Cell and Tissue Research·J C Sipe, R Y Moore
Nov 1, 1979·Physiology & Behavior·K Von Der Porten, J R Davis
Nov 1, 1978·Pharmacology, Biochemistry, and Behavior·K M KantakH A Tilson
Jan 1, 1976·Annual Review of Pharmacology and Toxicology·H G Baumgarten, A Björklund
Jul 1, 1977·Experimental Neurology·K J KellarW R Mehler
Oct 24, 1975·Brain Research·M J BrownsteinJ S Kizer
Dec 26, 1975·Brain Research·L DescarriesK C Watkins
Apr 30, 1976·Brain Research·E T PierceJ A Hobson
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jul 1, 1974·The Journal of Comparative Neurology·L C ConradD W Pfaff
Jan 12, 1972·Nature: New Biology·D V CoscinaS P Grossman
Jan 1, 1973·Journal of Comparative and Physiological Psychology·B H Turner
Jan 1, 1973·Biochemical Pharmacology·M H KannengiesserJ P Raynaud
Oct 29, 1971·Science·J F MarshallP Teitelbaum
May 15, 1969·Annals of the New York Academy of Sciences·Y OomuraN Kobayashi
Jan 1, 1965·Progress in Biophysics and Molecular Biology·V P Whittaker
Oct 20, 1980·Life Sciences·S C Gerson, R J Baldessarini
May 1, 1980·Brain Research Bulletin·F C BaroneF E Barash
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·S C Veasey
Oct 1, 1962·Physiological Reviews·J OLDS
Nov 1, 1962·The American Journal of Physiology·W E GLADFELTER, J R BROBECK
Feb 1, 1963·The Journal of Physiology·P BAILLIE, S D MORRISON
Feb 9, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·K FUXE
Aug 30, 2008·Nutrition·Yasuhiko MinokoshiShiki Okamoto

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Citations

Jan 1, 1990·Journal of Neural Transmission. General Section·I M McIntyre, T R Norman
Jan 1, 1984·Journal of Neuroscience Research·C Beas-ZarateA Feria-Velasco

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