Serotonergic manipulations in experimental neoplastic spinal cord compression

Journal of Neurosurgery
T Z Siegal, T Siegal

Abstract

The effects of differing strategies of serotonergic manipulation on vascular permeability, prostaglandin E2 (PGE2) synthesis, and the clinical course are evaluated in an experimental model of neoplastic spinal cord compression in rats. Serotonergic manipulations include in vivo inhibition of serotonin (5-HT) synthesis by p-chlorophenylalanine (p-CPA) and in vivo blockage of serotonin type 2 (5-HT2) receptors either by the selective antagonist ketanserin or by cyproheptadine. In paralyzed rats, the ratio of 5-hydroxyindole-3-acetic acid (5-HIAA) to 5-HT is significantly elevated in the compressed segments, suggesting that 5-HT utilization is increased. Treatment with p-CPA attenuates spinal 5-HT levels by 62.8% +/- 5.1% (mean +/- standard deviation) and reduces the elevated 5-HIAA:5-HT ratio to the normal value. The increased synthesis of PGE2 observed in the compressed cord is unaffected by p-CPA or ketanserin treatment but is markedly attenuated by cyproheptadine. Ketanserin reduces the 10-fold increase in spinal cord permeability observed in paralyzed rats in a clearly dose-related manner. If given at the first sign of neurological dysfunction, ketanserin delays the onset of paraplegia with the 1-mg/kg dose being clearly supe...Continue Reading

References

May 1, 1977·Neurology·Y UshioW R Shapiro
Jan 1, 1990·Journal of Neurotrauma·D X LiuD J McAdoo
Jan 1, 1991·Journal of Neurotrauma·S K SalzmanW P Bunnell
Jan 1, 1991·Journal of Neurology·E J Mylecharane
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·A FrazerB B Wolfe
Jan 1, 1988·Journal of Cardiovascular Pharmacology·T Hedner, B Persson
Dec 1, 1988·Journal of Neuro-oncology·D E Weissman, C Stewart
Jan 1, 1988·Annual Review of Neuroscience·S J Peroutka
Jan 1, 1986·Behavioral and Neural Biology·J A Deutsch, S Jang Ahn
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S R CoughlinL Levine

Citations

Jan 1, 1995·International Journal of Radiation Oncology, Biology, Physics·T Z Siegal, M R Pfeffer
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Z Siegal
Jul 9, 2016·American Journal of Infection Control·Kelley GarnerTerry Yamauchi

Related Concepts

Vascular Permeability
Viternum
Oradexon
Dose-Response Relationship, Drug
Hydroxyindoleacetic Acid
R-41,468
Fenclonine, (D)-Isomer
Rats, Inbred F344
Hydroxytryptamine
Serotonin Antagonists

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.