Serotonergic measures in cyclosporine A treated rats

Thrombosis Research
D UedaK Kawabe

Abstract

Whole blood and plasma serotonin (5-HT), its major metabolite--5-hydroxyindoleacetic acid (5-HIAA), renal cortical blood flow, serum creatinine and whole blood cyclosporine A (CyA) levels were investigated in rats administered with CyA at a dose of 5 mg/kg b.w. or 10 mg/kg b.w. for 14 consecutive days. Serum creatinine remained unaltered during CyA treatment and no apparent changes in excised kidneys were found. Dose-dependent increases in whole blood and plasma 5-HT as well as whole blood 5-HIAA levels were observed. Renal cortical blood flow declined significantly and correlated inversely with whole blood 5-HT and 5-HIAA as well as with plasma 5-HT. Whole blood 5-HT was positively related to whole blood CyA levels. Taking all these data into account and considering the fact that 5-HT is a potent vasoconstrictor, a possible role of this amine in the pathogenesis of renal ischemia during CyA administration is suggested.

References

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Citations

Sep 15, 1998·Kidney International. Supplement·M VerbekeN Lameire
May 1, 1996·International Journal of Urology : Official Journal of the Japanese Urological Association·S MugiyaA Takada
Jul 13, 2000·Journal of Cardiovascular Pharmacology·F ReisF Teixeira

Related Concepts

Metazoa
Krebiozen
Hydroxyindoleacetic Acid
Kidney Diseases
Renal Blood Flow
Hydroxytryptamine
Vascular Constriction (Function)
Restasis
Rats, Wistar
Rats, Laboratory

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