PMID: 7541832Mar 1, 1995Paper

Serotonergic modulation of locust motor neurons

Journal of Neurophysiology
D Parker

Abstract

1. The effects of the putative endogenous neuromodulator serotonin (5-HT) on the fast extensor and flexor tibiae motor neurons in the locust (Schistocerca gregaria) metathoracic ganglion, were analyzed. 2. 5-HT consistently increased the duration of the fast extensor spike and usually reduced the afterhyperpolarization, although this effect was less consistent. The spike broadening in the fast extensor was associated with an increase in the amplitude of the excitatory postsynaptic potential (EPSP) evoked monosynaptically in the flexor motor neurons by fast extensor stimulation. 5-HT also increased the membrane resistance of the fast extensor and flexor tibiae motor neurons. 3. The effects of 5-HT were mimicked by bath application of the 5-HT uptake inhibitor imipramine, and blocked by the 5-HT receptor antagonist ketanserin. The effects were also mimicked by dibutryl cyclic AMP, a membrane permeant analogue of cyclic AMP, and by the phosphodiesterase inhibitor 3-isobutyl-1-methyl-xanthine, but not by dibutryl cyclic GMP. The 5-HT-dependent modulation was blocked by the protein kinase A inhibitor H8. In addition, injection of cyclic AMP into the fast extensor or a flexor motor neuron could mimic the effects of 5-HT on these neur...Continue Reading

Citations

Jan 26, 2002·Microscopy Research and Technique·Uwe Homberg
Mar 15, 2001·Journal of Neurophysiology·J W Barclay, R M Robertson
Dec 13, 2005·Journal of Neurophysiology·Guisheng ZhongRonald M Harris-Warrick
Dec 19, 2014·Proceedings. Biological Sciences·Stephen M Rogers, Swidbert R Ott
Dec 18, 2001·Journal of Neurobiology·B S WuR M Robertson
Aug 15, 2014·Journal of Biosciences·Sufia Sadaf, Gaiti Hasan
Jan 26, 2002·Microscopy Research and Technique·Thomas Roeder
Oct 22, 2003·Journal of Insect Physiology·Amy E M NewmanR Meldrum Robertson
Nov 13, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Liselotte KaufmannHartmut Kayser

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