Serotonergic modulation of resting state default mode network connectivity in healthy women

Amino Acids
K HelmboldF D Zepf

Abstract

The default mode network (DMN) plays a central role in intrinsic thought processes. Altered DMN connectivity has been linked to diminished cerebral serotonin synthesis. Diminished brain serotonin synthesis is further associated with a lack of impulse control and various psychiatric disorders. Here, we investigated the serotonergic modulation of intrinsic functional connectivity (FC) within the DMN in healthy adult females, controlling for the menstrual cycle phase. Eighteen healthy women in the follicular phase (aged 20-31 years) participated in a double-blind controlled cross-over study of serotonin depletion. Acute tryptophan depletion (ATD) and a balanced amino acid load (BAL), used as the control condition, were applied on two separate days of assessment. Neural resting state data using functional magnetic resonance imaging (fMRI) and individual trait impulsivity scores were obtained. ATD compared with BAL significantly reduced FC with the DMN in the precuneus (associated with self-referential thinking) and enhanced FC with the DMN in the frontal cortex (associated with cognitive reasoning). Connectivity differences with the DMN between BAL and ATD in the precentral gyrus were significantly correlated with the magnitude of ...Continue Reading

References

Nov 1, 1987·Journal of Neurochemistry·Q R SmithS I Rapoport
Oct 1, 1983·Physiological Reviews·W M Pardridge
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E T Rolls
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Nov 27, 2001·Biological Psychiatry·M A Lee, H Y Meltzer
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Jan 28, 2004·Annual Review of Psychology·Walter Mischel
Apr 28, 2004·Psychoneuroendocrinology·Anna-Carin WihlbäckOlav Spigset
Jun 15, 2004·NeuroImage·Taylor W SchmitzSterling C Johnson
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Sep 2, 2005·Nature Reviews. Neuroscience·Morten L Kringelbach
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Jul 18, 2006·Current Pharmaceutical Design·J A J SchmittW J Riedel
Aug 11, 2006·Journal of Neurophysiology·Justin L VincentRandy L Buckner
Jan 20, 2007·Science·Malia F MasonC Neil Macrae
Oct 3, 2007·Biological Research for Nursing·G C Lasiuk, K M Hegadoren
Dec 22, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Raymond C K ChanEric Y H Chen
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Molly J CrockettTrevor W Robbins
Dec 15, 2010·Schizophrenia Research·Fabien C SchneiderFrançois Lang
Dec 21, 2010·Trends in Cognitive Sciences·Amit EtkinRaffael Kalisch
Dec 28, 2010·Journal of Affective Disorders·Cédric LemognePhilippe Fossati
Dec 8, 2011·Annals of the New York Academy of Sciences·Geoffrey SchoenbaumMichael A McDannald
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robin L Carhart-HarrisDavid J Nutt
Jul 14, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Aron K BarbeyJordan Grafman
Jul 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alex FornitoJon S Simons
Nov 13, 2012·Trends in Cognitive Sciences·Alan AnticevicJohn H Krystal
Mar 29, 2014·PloS One·Christian ScharingerLukas Pezawas
Apr 15, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K HelmboldF D Zepf
May 21, 2015·The International Journal of Neuropsychopharmacology·C L SanchezF D Zepf

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Citations

Jan 23, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Caroline S HildebrandtFlorian D Zepf
Oct 9, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·W KönigschulteF D Zepf
Mar 12, 2019·Frontiers in Neuroscience·Martin KlasenKlaus Mathiak

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