Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia

Neuroscience
Nina NevalainenIngrid Strömberg

Abstract

The 5-HT (5-hydroxytryptamine) system has been assigned a key role in the development of 3,4-dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia, mainly due to 5-HT neuronal ability to decarboxylate l-DOPA into dopamine. Nevertheless, knowledge of l-DOPA-induced events that could lead to development of dyskinesias are limited and therefore the present work has evaluated (i) the role of the 5-HT system in l-DOPA-derived dopamine synthesis when dopamine neurons are present, (ii) l-DOPA-induced effects on striatal dopamine release and clearance, and on 5-HT nerve fiber density, and (iii) the behavioral outcome of altered 5-HT transmission in dyskinetic rats. Chronoamperometric recordings demonstrated attenuated striatal l-DOPA-derived dopamine release (∼30%) upon removal of 5-HT nerve fibers in intact animals. Interestingly, four weeks of daily l-DOPA treatment yielded similar-sized dopamine peak amplitudes in intact animals as found after a 5-HT-lesion. Moreover, chronic l-DOPA exposure attenuated striatal 5-HT nerve fiber density in the absence of dopamine nerve terminals. Furthermore, fluoxetine-induced altered 5-HT transmission blocked dyskinetic behavior via action on 5-HT1A receptors. Taken together, the results indicate a...Continue Reading

References

Jan 9, 1984·Brain Research·G A GerhardtR N Adams
Oct 1, 1995·Neurology·F DurifY Agid
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J NirenbergV M Pickel
Feb 1, 1994·Clinical Neuropharmacology·V BonifatiG Meco
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J E Ahlskog, M D Muenter
Oct 22, 2002·Expert Opinion on Pharmacotherapy·Thomas Müller
Aug 27, 2004·Brain : a Journal of Neurology·Raúl de la Fuente-FernándezA Jon Stoessl
Mar 26, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·William Bara-JimenezThomas N Chase
Sep 3, 2005·Synapse·Tiziana AntonelliLuca Ferraro
Sep 1, 2006·Journal of Neurochemistry·M Angela Cenci, Martin Lundblad
Nov 10, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzHermann Russ
Apr 25, 2007·Brain : a Journal of Neurology·Manolo CartaAnders Björklund
Oct 28, 2008·Brain : a Journal of Neurology·Ana MuñozManolo Carta
Feb 7, 2009·Journal of Neurochemistry·Martin LundbladIngrid Strömberg
Feb 7, 2009·Parkinsonism & Related Disorders·Laurent GrégoireThérèse Di Paolo
Jan 26, 2010·Neurobiology of Disease·Sylvia NavaillesPhilippe De Deurwaerdère
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Manolo CartaAnders Björklund
Oct 1, 2010·Annals of Neurology·Daniella RylanderM Angela Cenci
Dec 7, 2010·Neuropharmacology·Brigitte SpinnewynPierre-Etienne Chabrier

❮ Previous
Next ❯

Citations

Feb 28, 2016·Neurology·Andreas-Antonios RoussakisPaola Piccini
Dec 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Eugene V MosharovDavid Sulzer
Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan
May 26, 2017·Expert Opinion on Investigational Drugs·Silvia CerriFabio Blandini
Feb 6, 2018·Journal of Neural Transmission·Annalisa PinnaNicola Simola
Jun 21, 2018·The European Journal of Neuroscience·Tanuja Bordia, Xiomara A Perez
Sep 27, 2019·Journal of Movement Disorders·Michael L MartiniFiona Gupta
Oct 28, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Han Soo YooPhil Hyu Lee
Mar 10, 2021·British Journal of Pharmacology·Sergio Vegas-SuárezLuisa Ugedo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.