Serotonergic Neuroplasticity in Alcohol Addiction

Brain Plasticity
Arnauld BelmerSelena E Bartlett

Abstract

Alcohol addiction is a debilitating disorder producing maladaptive changes in the brain, leading drinkers to become more sensitive to stress and anxiety. These changes are key factors contributing to alcohol craving and maintaining a persistent vulnerability to relapse. Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter widely expressed in the central nervous system where it plays an important role in the regulation of mood. The serotonin system has been extensively implicated in the regulation of stress and anxiety, as well as the reinforcing properties of all of the major classes of drugs of abuse, including alcohol. Dysregulation within the 5-HT system has been postulated to underlie the negative mood states associated with alcohol use disorders. This review will describe the serotonergic (5-HTergic) neuroplastic changes observed in animal models throughout the alcohol addiction cycle, from prenatal to adulthood exposure. The first section will focus on alcohol-induced 5-HTergic neuroadaptations in offspring prenatally exposed to alcohol and the consequences on the regulation of stress/anxiety. The second section will compare alterations in 5-HT signalling induced by acute or chronic alcohol exposure durin...Continue Reading

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Citations

Apr 2, 2020·Bioelectronic Medicine·Bettina HabeltIvan Minev
Jun 5, 2020·Psychopharmacology·Junchao TongStephen J Kish
Feb 13, 2021·Birth Defects Research·Bernice AsieduEliton Chivandi
Jan 26, 2021·Frontiers in Physiology·Soo K ShinFranklin D West
Apr 20, 2021·Neuroscience Insights·Kristin M Scaplen, Emily Petruccelli

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