Serotonergic projections to the retina of rat and goldfish

Neurochemistry International
L Lima, M Urbina

Abstract

Serotonin amacrine cells have been described in the retina of vertebrates, except mouse and rat. Moreover, serotonin immunoreactive fibers have been reported in the optic nerve of rodents, frog and stingray. The purpose of this work was to study serotonin dorsal raphe nucleus projections to the retina, and to determine whether this pathway occurs in teleosts. The existence of specific connections was investigated in the rat and in the goldfish by the use of the neurotoxic substance 5,7-dihydroxytryptamine followed by monoamines determination in the retina by HPLC. The administration of 5,7-dihydroxytryptamine into the central or the lateral area of the rat dorsal raphe nucleus decreased serotonin levels in the raphe area and in the hippocampus, but only the bilateral injection into the dorsal raphe nucleus decreased it in the retina. In the goldfish, the injection of 5,7-dihydroxytryptamine into the optic tectum decreased serotonin concentration in situ and in the retina. The binding of [3H]paroxetine, a marker of serotonin transporter, was reduced in the retina of both species after the central treatment with the neurotoxic substance. In addition, the administration of the serotonin precursor 5-hydroxytryptophan into the optic...Continue Reading

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Citations

Apr 6, 2001·Clinical Neuropharmacology·D OffenE Melamed
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·R GalambosG Juhász
Nov 8, 2002·Journal of Neurochemistry·Evelyne ChanutClaudine Versaux-Botteri
Sep 13, 2008·The International Journal of Neuroscience·Magor L LörinczGábor Juhász
Dec 4, 2003·The Journal of Comparative Neurology·Monique MédinaDom Miceli
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Aug 1, 2006·Current Eye Research·Matthew J GastingerDavid W Marshak
Dec 1, 2004·Microscopy Research and Technique·U Behrens, H-J Wagner
Sep 7, 2021·Frontiers in Behavioral Neuroscience·Eric ArsenaultBenoit Labonté

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