Serotonergic receptor upregulation in cerebral cortex and down regulation in brainstem of streptozotocin induced diabetic rats: antagonism by pyridoxine and insulin

Neuroscience Letters
Pretty Mary AbrahamC S Paulose

Abstract

Insulin secretion and glucose homeostasis is implicated through serotonergic function. Pyridoxine is involved in decarboxylation step in synthesis of serotonin. The present study was carried out to find the role of insulin in combination with pyridoxine on the concentrations of 5-HT and 5-HIAA, 5-HT receptor binding, 5-HTT gene expression and immunohistochemistry studies in the cerebral cortex and brainstem of streptozotocin induced diabetic rats. 5-HT content showed a significant decrease with a significant increase in 5-HIAA in cerebral cortex (p<0.01) and brain stem (p<0.001) in diabetic rats. 5-HT receptor binding parameters, B(max) and K(d), showed a significant decrease (p<0.001) in diabetic rats in cerebral cortex whereas in brainstem it showed a significant increase (p<0.001) compared to control. Gene expression studies of 5-HTT in cerebral cortex showed a significant down regulation (p<0.001) and in brainstem an upregulation (p<0.001) in diabetic rats compared to control. Insulin and pyridoxine treatment to diabetic rats reversed the 5-HT content, B(max), K(d) and gene expression of 5-HTT confirmed by immunohistochemistry studies in cerebral cortex and brainstem to near control. Thus our results suggest that pyridoxine...Continue Reading

References

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Aug 30, 2007·Nature Neuroscience·Turhan Canli, Klaus-Peter Lesch

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Citations

Jan 3, 2012·Molecular and Cellular Endocrinology·Ioannis PapazoglouKyriaki Gerozissis
Aug 30, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Unji LeeHee E Kang
Jul 31, 2021·World Journal of Diabetes·Taymour Mostafa, Ibrahim A Abdel-Hamid

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