Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

ACS Chemical Neuroscience
Steven C LeiserConnie Sanchez

Abstract

It has been known for several decades that serotonergic neurotransmission is a key regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of novel serotonin (5-HT) receptor subtypes, as well as an expanding knowledge of their expression level in certain brain regions and localization on certain cell types, their involvement in cognitive processes is still emerging. Of particular interest are cognitive processes impacted in neuropsychiatric and neurodegenerative disorders. The prefrontal cortex (PFC) is critical to normal cognitive processes, including attention, impulsivity, planning, decision-making, working memory, and learning or recall of learned memories. Furthermore, serotonergic dysregulation within the PFC is implicated in many neuropsychiatric disorders associated with prominent symptoms of cognitive dysfunction. Thus, it is important to better understand the overall makeup of serotonergic receptors in the PFC and on which cell types these receptors mediate their actions. In this Review, we focus on 5-HT receptor expression patterns within the PFC and how they influence cognitive behavior and neurotransmission. We further discuss the net effects of vortioxetine, an antidepressant a...Continue Reading

References

Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Mar 1, 1995·Behavioural Brain Research·T Steckler, A Sahgal
Apr 1, 1994·Brain Research. Molecular Brain Research·M PompeianoG Mengod
Jun 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·A T BruinvelsD Hoyer
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·A Meneses, E Hong
May 1, 1996·Psychopharmacology·B W BalleineA Dickinson
Jun 3, 1996·European Journal of Pharmacology·K WedzonyK Gołembiowska
Apr 1, 1997·Current Opinion in Neurobiology·M C Buhot
May 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S RuotsalainenP Riekkinen
Nov 7, 1998·British Journal of Pharmacology·I MisaneS O Ogren
Dec 29, 1998·European Journal of Pharmacology·B J FranckenJ E Leysen
Jan 14, 1999·Neuroscience Letters·A VysokanovD J Surmeier
Mar 20, 1999·Neurobiology of Learning and Memory·A Meneses, E Hong
Jun 24, 1999·The Journal of Comparative Neurology·V Cornea-HébertL Descarries

❮ Previous
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Citations

Mar 8, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gennady N SmaginConnie Sánchez
Jul 15, 2015·ACS Chemical Neuroscience·Anne M Andrews
May 21, 2015·The International Journal of Neuropsychopharmacology·Viacheslav TerevnikovJan-Henry Stenberg
May 15, 2016·Journal of Neurotrauma·William J DurhamBrent E Masel
Jun 6, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kristian Gaarn du JardinConnie Sanchez
Aug 11, 2016·Drug Discovery Today·Priya BawaViness Pillay
Aug 9, 2016·Postgraduate Medicine·Gregory MattinglyElizabeth Q Anderson
Feb 16, 2017·ACS Chemical Neuroscience·Anne Milasincic Andrews
Feb 6, 2017·The International Journal of Neuropsychopharmacology·Yan LiMaria Gulinello
Jun 23, 2018·Biomolecules & Therapeutics·Zhenzhen HuKi-Wan Oh
Mar 14, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Bill McCarberg, John Peppin
Apr 3, 2019·The International Journal of Eating Disorders·Jon E GrantSamuel R Chamberlain
May 28, 2019·The International Journal of Neuropsychopharmacology·Yue-Qing ZhouHao-Wei Shen
May 13, 2017·Pharmacological Reports : PR·Magdalena Sowa-KućmaMagdalena Koperny
Mar 28, 2017·Reviews in the Neurosciences·Alfredo Meneses
Dec 10, 2016·Frontiers in Neuroscience·Giuseppe Di GiovanniPhilippe De Deurwaerdère
Jan 15, 2019·Forensic Toxicology·Karolina Noworyta-SokołowskaKrystyna Gołembiowska
Sep 7, 2019·The European Journal of Neuroscience·Yu-Hao XuYue-Feng Li
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annamaria LubelskaJadwiga Handzlik
Dec 13, 2016·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Shubo DongHanyue Yang
Jan 23, 2018·Frontiers in Neural Circuits·Daniel W SparksEvelyn K Lambe
Jul 19, 2018·Frontiers in Neuroscience·Zvi R ShapiroMatthew S Matell
Jan 13, 2019·International Journal of Environmental Research and Public Health·Soe-Minn HtwayTin-Tin Win-Shwe
Dec 16, 2018·Translational Psychiatry·Mark D UnderwoodVictoria Arango
Oct 7, 2020·Obesity·Hartej GillRoger S Mcintyre
Jan 1, 2019·Journal of Chemical Neuroanatomy·Pollyana C LealJosé R Santos
Mar 5, 2021·The European Journal of Neuroscience·Verónica Pastor, Jorge Horacio Medina
Jan 27, 2017·Translational Neuroscience·Dubravka Švob ŠtracDorotea Mück-Šeler
Jun 14, 2021·Molecular Neurobiology·Zeinab VahidiniaAbolfazl Azami Tameh
Jul 11, 2021·Revista española de anestesiología y reanimación·A Alcántara Montero, S R Pacheco de Vasconcelos

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