Serotonergic signalling in the stomach and duodenum of patients with gastroparesis

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
N van LelyveldMelvin Samsom

Abstract

Serotonin (5-HT) is involved in the regulation of motoric and sensory functions of the upper gastrointestinal tract. The aim of the current study was to determine whether serotonergic signalling is altered in patients with idiopathic gastroparesis. Mucosal biopsy specimens were collected from the duodenum, antrum and fundus of 11 patients with idiopathic gastroparesis and 11 healthy controls. Neuroendocrine cells, specifically 5-HT producing cells, were counted after immunohistochemistry, and non-neuronal mRNA expression levels of tryptophan hydroxylase (TPH)-1, 5-HT transport protein (SERT), 5-HT3 and 5-HT4 receptor were quantified by real time RT-PCR. The number of 5-HT producing cells was comparable between patients and controls. No difference in expression of TPH-1 (rate limiting enzyme in 5-HT biosynthetic pathway) and SERT (responsible for 5-HT uptake) was found between patients and controls (P > 0.05). In the duodenum, the expression of the 5-HT3 receptor subunits and the 5-HT4 receptor was comparable between both groups. However, the 5-HT4(c) splice variant was expressed more abundantly in healthy controls compared to patients (P = 0.015). This study suggests that the delayed gastric emptying and upper abdominal symptom...Continue Reading

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Citations

Sep 22, 2009·Current Gastroenterology Reports·William L Hasler
Sep 4, 2009·Current Opinion in Gastroenterology·Jan Tack
Feb 24, 2012·Alimentary Pharmacology & Therapeutics·J TackV Stanghellini
Mar 22, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea M SantangeloAngela C Roberts
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Dec 2, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Tara Swami, H Christian Weber
Feb 19, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natalija MilkovaJi-Hong Chen
Jan 15, 2019·Scandinavian Journal of Gastroenterology·Mattis BekkelundLars Aabakken
Mar 20, 2021·Expert Review of Endocrinology & Metabolism·Mahesh GajendranRichard McCallum
Jun 3, 2021·International Journal of Molecular Sciences·Ann-Katrin HolikVeronika Somoza
Jun 13, 2020·The American Journal of the Medical Sciences·Zorisadday GonzalezRichard W McCallum

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