PMID: 2459577Jan 1, 1988

Serotonergic status in human blood

Life Sciences
J OrtizE Gelpí


Preliminary data on the existence of a plasma pool of serotonin (5HT) in human blood has been confirmed in a descriptive study of two distinctive pools of 5HT (plasma and platelet), and its metabolite 5-hydroxyindoleacetic acid (5HIAA), in the blood of 175 healthy individuals. Plasma 5HT (0.93 +/- 0.67 ng/mL, X +/- S.D.) shows a significant but low correlation with platelet 5HT (711 +/- 319 ng/10(9) platelets) (r=0.29, p less than 0.001). Diastolic blood pressure correlated significantly with plasma 5HT (r=0.51, p less than 0.05) and whole blood 5HT (r=0.52, p less than 0.05) in older individuals (50-65 years) but not in the whole group (r=0.052, n.s.). Differences between sexes include plasma 5HT, whole blood 5HT (both higher in women) and plasma 5HIAA (lower in women) and may reflect a differential whole body 5HT function. The effect of meal consumption and a peripheral 5HT synthesis inhibitor (carbidopa) in four human subjects has also been tested. Carbidopa (0.7 mg/kg) significantly lowers the plasma pool of 5HT (mean change -33%) 2 hr. after administration, while platelet 5HT is unchanged. These data support the existence of a human plasma 5HT pool, with a rapid turnover, different from the 5HT in platelets (slow turnover,...Continue Reading


Mar 1, 1993·Biological Psychiatry·P C WaldmeierH Howald
Jan 1, 1989·Life Sciences·B JernejS Kveder
Apr 22, 1994·Journal of Chromatography. B, Biomedical Applications·E F Marshall, M Leitch
Dec 1, 1991·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P SimonssonR Ohman
Jan 11, 2001·Physiology & Behavior·P F Frohlich, C M Meston
Jan 19, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·X Páez, L Hernández
Aug 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·D FekkesL Pepplinkhuizen
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J C AlvarezO Spreux-Varoquaux
Jan 1, 1990·Acta Psychiatrica Scandinavica·D BaillyP J Parquet
Nov 26, 1998·The British Journal of Ophthalmology·C W StorimansJ A Oosterhuis
Sep 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·G M Van Kempen
Jan 10, 2012·Neuropsychobiology·Michiko KanoShin Fukudo
Feb 10, 2012·PloS One·Way K W LauCOPD Study Group of the Hong Kong Thoracic Society
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian J MickeyJon-Kar Zubieta
Sep 29, 2009·Neuropharmacology·Scott F Stoltenberg, Joanna M Vandever
May 1, 2008·The European Journal of Neuroscience·Yasushi NakataniHideho Arita
Aug 2, 2006·Acta Anaesthesiologica Scandinavica·O Naesh
Jun 5, 2007·Biological Psychiatry·Kelly P CosgroveJulie K Staley
Mar 30, 2013·NeuroImage·Dustin W WootenBradley T Christian
Nov 3, 2011·Biochemical and Biophysical Research Communications·Yukiko NakamuraShoichi Shimada
Apr 14, 2010·Journal of Psychosomatic Obstetrics and Gynaecology·Hiromi KikuchiHideho Arita
Oct 17, 2012·Neurochemistry International·Fudong Liu, Louise D McCullough
Nov 5, 2004·American Journal of Human Genetics·Lauren A WeissCarole Ober
Mar 22, 2007·Respiratory Physiology & Neurobiology·Benjamin R SeebartMary Behan
Jul 17, 2012·Obesity Facts·Stephanie HodgeBarbara J Stewart-Knox
Dec 20, 2017·Scientific Reports·Marion BenabouThomas Bourgeron
Sep 14, 2002·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·U J GerhardB Blanz
Apr 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emili BanerjeeKrishnadas Nandagopal
Jan 9, 2020·Journal of Psychopharmacology·Mason M SilveiraCatharine A Winstanley
Feb 2, 2010·The Veterinary Record·D AlberghinaA D Ellis

Related Concepts

Age Factors
Blood Platelets
Diastolic Blood Pressure
Hydroxyindoleacetic Acid
Platelet Count Measurement

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.