Serotonergic stimulation of the rat hypothalamo-pituitary-adrenal axis: interaction between 5-HT1A and 5-HT2A receptors

Annals of the New York Academy of Sciences
Jens D MikkelsenAlexander Kiss

Abstract

Acute stimulation of the hypothalamo-pituitary-adrenal (HPA) axis by selective serotonin reuptake inhibitors (SSRIs) is mediated by several postsynaptic 5-HT receptor subtypes. Activation of 5-HT(1A) and 5-HT(2A) receptors increases plasma corticosterone levels, and it is likely that these receptor subtypes are central to mediating the effects of SSRIs. To study the interaction of these receptors, rats were administered with the 5-HT(1A/7) agonist 8-OH-DPAT (0.05 to 1.25 mg/kg), the 5-HT(2A/C) agonist DOI (0.25 to 5 mg/kg), or a mixture of both compounds, and trunk blood was taken 60 min later. The two compounds given in combination produced a lower increase in corticosterone than DOI does alone. DOI and 8-OH-DPAT also produced a marked induction of c-Fos in the paraventricular nucleus (PVN), but the induction was not different if the two compounds were given together. These data show that the two serotonin receptor subtypes affect the HPA axis via a central target. In conclusion, 5-HT(1A) and 5-HT(2A) receptors regulate corticotrophin-releasing hormone (CRH) neurons via distinct but strongly interacting pathways, probably converging on the same neurons in the hypothalamus.

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Citations

Jan 12, 2011·Sleep & Breathing = Schlaf & Atmung·Stephane BesnardChristian Gestreau
Jan 7, 2010·Journal of Molecular Neuroscience : MN·Virginia R Falkenberg, Mangalathu S Rajeevan
Sep 8, 2007·Lancet·Daniel J BrotmanIlan S Wittstein
Mar 13, 2008·American Journal of Physiology. Endocrinology and Metabolism·Nicole M SandersDianne P Figlewicz
Dec 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qun XuLing-Dong Kong
Jun 16, 2009·Seminars in Nephrology·David B Mount
Jan 21, 2006·Brain Research·Lynda UphouseBruce Grossie
Jun 15, 2007·The European Journal of Neuroscience·Sara S N HoWing-Ho Yung
Mar 17, 2018·Frontiers in Pharmacology·Emmanuelle A D SchindlerDeepak C D'Souza
Jun 29, 2016·Brain Plasticity·Arnauld BelmerSelena E Bartlett
Aug 23, 2020·International Journal of Molecular Sciences·Sabrina I HanswijkJudith R Homberg
Oct 6, 2020·Clinical Obstetrics and Gynecology·Alvaro Ruiz-Zambrana, Sarah L Berga

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