Serotonin-1A receptor function in the dorsal raphe nucleus following chronic administration of the selective serotonin reuptake inhibitor sertraline

Journal of Neurochemistry
Dania V RossiJulie G Hensler

Abstract

Serotonin-1A (5-HT(1A) receptors in the dorsal raphe nucleus (DRN) function as somatodendritic autoreceptors, and therefore play a critical role in controlling serotonergic cell firing and serotonergic neurotransmission. We hypothesized that a decrease in the capacity of 5-HT(1A) receptors to activate G proteins was a general mechanism by which 5-HT(1A) receptors in the DRN are desensitized following chronic administration of selective serotonin reuptake inhibitors (SSRIs). Using in vivo microdialysis, we found that the ability of the 5-HT(1A) receptor agonist 8-hydroxydipropylaminotetralin hydrobromide (8-OH-DPAT) (0.025 mg/kg, s.c.) to decrease extracellular 5-HT levels in striatum was attenuated following chronic treatment of rats with the SSRIs sertraline or fluoxetine. This apparent desensitization of somatodendritic 5-HT(1A) autoreceptor function was not accompanied by a decrease in 5-HT(1A) receptor sites in the coupled, high-affinity agonist state as measured by the binding of [3H]8-OH-DPAT. In marked contrast to what was observed following chronic administration of fluoxetine, 5-HT(1A) receptor-stimulated [(35)S]GTPgammaS binding in the DRN was not altered following chronic sertraline treatment. Thus, desensitization o...Continue Reading

References

Jan 1, 1992·Journal of Neural Transmission. General Section·J Maj, E Moryl
Jan 1, 1990·Annals of the New York Academy of Sciences·G K AghajanianK Rasmussen
Nov 10, 1987·European Journal of Pharmacology·R B Innis, G K Aghajanian
Aug 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·E Le PoulL Lanfumey
Mar 1, 1996·International Clinical Psychopharmacology·P Baumann
Jun 14, 2000·European Journal of Pharmacology·T I CremersH V Wikström
Dec 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·I HervásF Artigas
Oct 6, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·G TournelM Lhermitte
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie G Hensler
Feb 11, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mostafa El MansariNasser Haddjeri
Jul 23, 2005·The International Journal of Neuropsychopharmacology·Dania V RossiJulie G Hensler

❮ Previous
Next ❯

Citations

Jan 22, 2013·ACS Chemical Neuroscience·Stefanie C AltieriAnne M Andrews
Feb 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eduardo A PinedaAndréy M Mazarati
Mar 31, 2009·Experimental Neurology·Fabricia Viana FonsecaLuís Carlos Reis
May 12, 2009·Progress in Neurobiology·Jonathan SavitzWayne C Drevets
Jul 2, 2011·British Journal of Pharmacology·Thibault RenoirAnthony J Hannan
Mar 31, 2011·Pharmacology & Therapeutics·Lynette C Daws, Georgianna G Gould
Nov 28, 2009·The International Journal of Neuropsychopharmacology·Janaina M ZanoveliHelio Zangrossi
Dec 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefanie C AltieriAnne M Andrews
May 1, 2020·Psychiatry Research·Brent M Kious, Amanda V Bakian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.