Serotonin (5-HT) enhances hippocampal noradrenaline (NA) release: evidence for facilitatory 5-HT receptors within the CNS

Naunyn-Schmiedeberg's Archives of Pharmacology
T J Feuerstein, G Hertting

Abstract

Slices of rabbit hippocampus were preincubated with 3H-noradrenaline (3H-NA), then superfused continuously in the presence of the noradrenaline (NA) uptake inhibitor (+)oxaprotilin and twice stimulated electrically. The stimulation induced tritium overflow was increased by the 5-HT receptor agonists, 5-HT, 2-methyl-5-HT and 5-carboxamidotryptamine in a concentration dependent manner; a tyramine-like displacement of NA by the 5-HT agonists was prevented by (+)oxaprotilin. The 5-HT M-receptor antagonists, MDL 72222 and ICS 205-930, inhibited the facilitatory effects of 5-HT agonists as well as the enhanced tritium overflow due to the selective 5-HT uptake inhibitor, 6-nitroquipazine: in each case, concentrations much higher than those required to block M-receptors of the periphery were necessary. At high concentrations MDL 72222, in contrast to ICS 205-930, seems to have alpha-adrenoceptor antagonistic activity. The 5-HT2 receptor antagonist, ketanserin, had no effect on 5-HT-induced facilitation of transmitter release; metitepin facilitated stimulation-evoked transmitter release per se both in the absence and presence of phentolamine. From our results we conclude that, as on peripheral nerve endings, also on central noradrenergi...Continue Reading

References

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Citations

Oct 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·M A TarangerS Z Langer
Feb 25, 1992·European Journal of Pharmacology·P MartinA J Puech
Nov 1, 1989·Physiology & Behavior·M I Gonzalez, M L Leret
Sep 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·P BoF Savoldi
Aug 13, 1997·European Journal of Pharmacology·D ShacharJ P Finberg
Feb 1, 1997·Pharmacology, Biochemistry, and Behavior·M G CutlerJ E Jackson
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·L Uphouse
Jan 4, 2001·Trends in Neurosciences·J A van Hooft, H P Vijverberg
Jan 1, 1996·The Journal of Clinical Psychiatry·P A Newhouse
Sep 12, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lydia C HarrisNajam A Sharif
Jan 1, 1990·Annals of the New York Academy of Sciences·R W Fuller, D T Wong
Sep 18, 2010·Hippocampus·José Carlos de MouraCarlos Gilberto Carlotti Júnior

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