PMID: 2105822Jan 1, 1990Paper

Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron

Brain Research
P W Sheldon, G K Aghajanian

Abstract

In a slice preparation of rat piriform cortex, both intracellular and extracellular techniques were used to examine the pharmacological and electrophysiological actions of serotonin (5-HT). Bath application of 5-HT resulted in either depolarization (57%), hyperpolarization (34%) or no change (9%) in membrane potential of cells in the pyramidal cell layer (layer II) of piriform cortex. Additionally, when KCl-containing electrodes were used, 5-HT induced an increase in depolarizing synaptic potentials in 41% of these cells. It was concluded that these potentials were reverse inhibitory post-synaptic potentials (IPSPs) because they were blocked by bicuculline and tetrodotoxin. The induction of IPSPs by 5-HT was blocked by the 5-HT2-selective antagonist ritanserin. By recording extracellularly in the presence of 5-HT, a group of 5-HT-activated, putative interneurons was found at the border of layers II and III of piriform cortex, 5-HT but not norepinephrine activation was blocked by ritanserin. The actions of 5-HT were mimicked by the 5-HT2 agonist alpha-methyl-5-HT; the 5-HT2 partial agonist, 2,5-dimethoxy-4-methyl-amphetamine had a small agonist action of its own and blunted the effect of 5-HT. Activation of a larger group of put...Continue Reading

References

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Citations

Jun 24, 1999·The Journal of Comparative Neurology·V Cornea-HébertL Descarries
Jan 1, 1993·Journal of Neural Transmission. General Section·L GiardinoL Calzà
Jun 1, 1996·Cellular and Molecular Neurobiology·G FinkJ P Quinn
Aug 1, 1996·Biological Psychiatry·H T NagamotoR Freedman
Apr 24, 1991·European Journal of Pharmacology·P Van den Hooff, M Galvan
Jul 23, 1991·European Journal of Pharmacology·S Benloucif, M P Galloway
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·R L Nogueira, F G Graeff
Dec 20, 1993·Behavioural Brain Research·F G GraeffR M Oliveira
Apr 1, 1994·Brain Research. Molecular Brain Research·M PompeianoG Mengod
Nov 1, 1992·Progress in Neurobiology·P T FrancisD M Bowen
Apr 1, 1992·Brain Research Bulletin·S KawanoH Yamashita
Jul 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·B E Summer, G Fink
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
Mar 17, 2000·Brain Research. Brain Research Reviews·G K Aghajanian, G J Marek
Dec 1, 1996·Progress in Neurobiology·W Löscher, U Ebert
Oct 9, 1999·Progress in Neurobiology·C Gottesmann

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