Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice

Lakshmi RajagopalHerbert Y Meltzer


Reversal learning (RL), a type of executive function, dependent on prefrontal cortical function, is impaired in rodents by subchronic (sc) treatment with the N-methyl-D-aspartate receptor antagonist, phencyclidine (PCP), a widely studied model of cognitive impairment in schizophrenia (CIS). The principal objective of this study was to determine the ability of serotonin (5-HT)1A partial agonism and 5-HT7 receptor antagonism to improve RL in scPCP-treated mice. Male C57BL/6J mice were trained on an operant RL (ORL) task, then received PCP, 10 mg/kg, or saline, bid, for 7 days, followed by a 7-day washout period. scPCP significantly diminished the percent correct responding, increased total incorrect trials, and total incorrect responses, in the reversal phase performance of the ORL task. Pre-treatment with the selective 5-HT1A partial agonist, tandospirone, or the selective 5-HT7 antagonist, SB269970, but not the 5-HT7 agonist, AS 19, reversed the scPCP-induced deficit in RL. Pre-treatment with atypical antipsychotic drug lurasidone, which is a 5-HT1A partial agonist and 5-HT7 antagonist, as well as a 5-HT2A and dopamine (D)2 antagonist, also reversed RL deficit in the scPCP-treated mice. Furthermore, the selective 5-HT1A antagon...Continue Reading


Dec 8, 2016·Behavioural Pharmacology·Alfredo Meneses
Aug 11, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lakshmi RajagopalHerbert Y Meltzer


Nov 1, 1991·The American Journal of Psychiatry·K L DavisM Davidson
Mar 1, 1988·Japanese Journal of Pharmacology·H ShimizuM Nakamura
Feb 1, 1994·Archives of General Psychiatry·A J SaykinR C Gur
May 1, 1993·Journal of Neurophysiology·E Tanaka, R A North
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Shallice, P Burgess
Jan 14, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J W NewcomerJ W Olney
Mar 12, 1999·Science·E E Smith, J Jonides
May 24, 2000·British Journal of Pharmacology·J J HaganD R Thomas
May 12, 2004·Brain and Cognition·L ClarkTrevor W Robbins
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jean-Claude BéïqueRodrigo Andrade
Nov 9, 2004·Schizophrenia Research·Michael F GreenRobert K Heaton
Mar 24, 2005·The International Journal of Neuropsychopharmacology·Neil D WoodwardDavid H Zald
Jun 7, 2005·Behavioural Brain Research·Georgina S Perez-García, Alfredo Meneses
Oct 29, 2005·The Journal of Comparative Neurology·Trevor W Robbins
Apr 1, 2006·Neuroscience and Biobehavioral Reviews·Alice EgertonJudith A Pratt
Apr 5, 2007·Reviews in the Neurosciences·Mufida El-GhundiSusan R George
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vasileios BoulougourisTrevor W Robbins
Dec 11, 2007·Trends in Cognitive Sciences·Roshan CoolsTrevor W Robbins
Mar 1, 2008·Behavioural Brain Research·Antonella GasbarriAlfredo Meneses
Apr 1, 2008·European Journal of Pharmacology·Gary LynchChristine M Gall
Aug 19, 2008·Behavioural Brain Research·Herbert Y Meltzer, Tomiki Sumiyoshi
Sep 6, 2008·Progress in Brain Research·Herbert Y Meltzer, Mei Huang
Mar 10, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Samantha L McLeanJoanna C Neill
May 21, 2009·Journal of Molecular Neuroscience : MN·Yong Kee ChoiFrank I Tarazi
Jun 27, 2009·Annual Review of Neuroscience·Trevor W Robbins, A F T Arnsten
Jul 25, 2009·Psychopharmacology·Samantha L McLeanJoanna C Neill
Nov 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Naomi A FinebergEric Hollander
Apr 21, 2010·The Journal of Pharmacology and Experimental Therapeutics·Tadashi IshibashiMitsutaka Nakamura

Related Concepts

Atypical Antipsychotic [EPC]
GBA2 wt Allele
Neurologic Manifestations
Prefrontal Cortex
Reaction Time
Cell Polarity
C57BL/6 Mouse
Serotonin 5-HT1A Receptor Antagonists

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