Serotonin (5-hydroxytryptamine) transporter inhibition causes bone loss in adult mice independently of estrogen deficiency

Menopause : the Journal of the North American Menopause Society
Stuart J WardenCharles H Turner

Abstract

Selective serotonin reuptake inhibitors (SSRIs) treat depression by antagonizing the serotonin (5-hydroxytryptamine) transporter (5-HTT). These drugs may also have skeletal effects given the presence of functional serotonergic pathways in bone and evidence demonstrating detrimental effects of SSRIs on postmenopausal bone changes. This study aimed to explore the influence of an SSRI (fluoxetine hydrochloride) on the bone changes associated with estrogen deficiency in adult mice. Adult, female, Swiss-Webster mice underwent ovariectomy (OVX) or sham OVX and were treated daily for 4 weeks with either fluoxetine hydrochloride (5 or 20 mg/kg) or a vehicle solution (control). In vivo assessments of hindlimb areal and tibial volumetric bone mineral density were performed at baseline and after 4 weeks of intervention. Femurs and lumbar vertebrae were subsequently removed and assessed ex vivo for bone mineral density and trabecular bone architecture and turnover. In vivo and ex vivo skeletal measures found no interactions between OVX (estrogen deficiency) and 5-HTT inhibition, indicating that the skeletal effects of these interventions were independent. 5-HTT inhibition had detrimental skeletal effects, with the fluoxetine-treated groups...Continue Reading

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Apr 1, 1995·Biological Psychiatry·U HalbreichK Wang
Nov 1, 1996·The American Journal of Psychiatry·L M KoranS Thiemann
Sep 24, 1998·The New England Journal of Medicine·P B ThapaW A Ray
Jun 2, 2001·The Journal of Biological Chemistry·I WestbroekP J Nijweide
Jul 17, 2001·Journal of the American Geriatrics Society·J RobbinsT Harris
Sep 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M AlexanderM Rosenblatt
Dec 4, 2001·Pharmacology·Ewa MalatynskaRichard J Knapp
Jul 2, 2002·Archives of Pediatrics & Adolescent Medicine·Naomi WeintrobZvi Dickerman
Dec 5, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew HolmesJacqueline N Crawley
Apr 30, 2003·Archives of Internal Medicine·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Jul 2, 2003·American Journal of Epidemiology·Richard HubbardAnne Tattersfield
Apr 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephanie C DulawaRene Hen
Jun 24, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Paul A. PirragliaDaniel E. Singer
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ricardo BattaglinoPhilip Stashenko
Nov 13, 2004·Journal of Clinical Psychopharmacology·Sebastian Schneeweiss, Philip S Wang
Jan 18, 2005·Journal of Biomechanics·Jennifer L SchrieferCharles H Turner
May 13, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jane A CauleyUNKNOWN Mr. OS Research Group
Jul 5, 2005·Endocrinology·Fang ChenAlfred A Reszka
Aug 9, 2005·Molecular and Cellular Endocrinology·Stuart J WardenCharles H Turner
Jan 13, 2006·Journal of Cellular Biochemistry·B I GustafssonU Syversen
Jan 18, 2006·The American Journal of Medicine·Lee S CohenHadine Joffe
Jan 26, 2006·Brain : a Journal of Neurology·Jeremy D Schmahmann, David Caplan
Jan 28, 2006·Gerontology·James M Ferguson, Heather Hill
Apr 28, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Claudia-Carolin WeberWalter E Müller
Oct 17, 2006·Journal of Cellular Biochemistry·R BattaglinoP Stashenko
Jan 24, 2007·Archives of Internal Medicine·J Brent RichardsUNKNOWN Canadian Multicentre Osteoporosis Study Research Group
Mar 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·N R MirzaK B Troelsen
Jun 27, 2007·Archives of Internal Medicine·Susan J DiemKristine E Ensrud
Jun 27, 2007·Archives of Internal Medicine·Elizabeth M HaneyUNKNOWN Osteoporotic Fractures in Men Study Group

❮ Previous
Next ❯

Citations

Jan 30, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M L O SheaE J Lenze
Apr 2, 2011·Calcified Tissue International·Susan J DiemUNKNOWN Study of Osteoporotic Fractures Research Group
Feb 7, 2009·Nature Medicine·Clifford J Rosen
Mar 7, 2009·The New England Journal of Medicine·Clifford J Rosen
Sep 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Michael Bliziotes
Dec 18, 2013·Brain : a Journal of Neurology·Sandra GuidiRenata Bartesaghi
Jun 5, 2012·Bone·R RizzoliP Vestergaard
Sep 17, 2015·Journal of Cellular Biochemistry·Tomas E MeijomeMelissa A Kacena
Sep 11, 2014·Journal of Cellular Physiology·Tomas E MeijomeMelissa A Kacena
Jul 3, 2013·L'Encéphale·H KerbageD Purper Ouakil
Feb 8, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·E M TsapakisE Tsiridis
May 22, 2009·Journal of Cellular Biochemistry·Valeria SibiliaFrancesca Guidobono
Mar 24, 2016·Molecular Therapy. Nucleic Acids·Daniel B HoffmannJens Gruber
Sep 1, 2015·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Giovana Carla Franzon FrigottoElisa Souza Camargoa
Jul 15, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Naja Wessel JacobsenBent Halling-Sørensen
May 3, 2015·European Journal of Pharmacology·Sona FeketeVladimir Palicka
Oct 1, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Lauren D GarfieldEric J Lenze
Aug 9, 2016·Current Osteoporosis Reports·Stuart J Warden, Robyn K Fuchs
Oct 16, 2016·Clinical Oral Implants Research·Bruno R ChrcanovicAnn Wennerberg
Jun 23, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sofie Schwan, Pär Hallberg
Nov 20, 2016·Journal of Dental Research·B R ChrcanovicA Wennerberg
Jan 10, 2017·Journal of Cellular Biochemistry·David J OlivosMelissa A Kacena
Jul 17, 2018·Journal of Cellular Biochemistry·David J OlivosLindsey D Mayo
Oct 6, 2018·Journal of Clinical Periodontology·Lina Abu NadaFaleh Tamimi
Dec 15, 2007·Journal of Applied Physiology·Y KasashimaA E Goodship
Oct 26, 2018·Fundamental & Clinical Pharmacology·Marzieh KhademiZahra Taghipour
Dec 28, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sooyeon LeePhilipp Leucht
May 1, 2009·Expert Review of Endocrinology & Metabolism·Briana Mezuk, Sherita Hill Golden
Apr 1, 2018·Journal of Mammary Gland Biology and Neoplasia·Samantha R Weaver, Laura L Hernandez
Sep 1, 2010·Expert Review of Endocrinology & Metabolism·Maria P Yavropoulou, Socrates E Papapoulos
May 6, 2016·Journal of Dental Research·B R ChrcanovicA Wennerberg
Nov 22, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Vivian Bradaschia-CorreaPhilipp Leucht
Dec 31, 2021·The Science of the Total Environment·Patricia I PintoD M Power

❮ Previous
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