Serotonin and cholecystokinin synergistically stimulate rat vagal primary afferent neurones

The Journal of Physiology
Y LiC Owyang

Abstract

Recent studies indicate that cholecystokinin (CCK) and serotonin (5-hydroxytryptamine, 5-HT) act via vagal afferent fibres to mediate gastrointestinal functions. In the present study, we characterized the interaction between CCK and 5-HT in the vagal primary afferent neurones. Single neuronal discharges of vagal primary afferent neurones innervating the duodenum were recorded from rat nodose ganglia. Two groups of nodose ganglia neurones were identified: group A neurones responded to intra-arterial injection of low doses of cholecystokinin octapeptide (CCK-8; 10-60 pmol); group B neurones responded only to high doses of CCK-8 (120-240 pmol), and were also activated by duodenal distention. CCK-JMV-180, which acts as an agonist in high-affinity states and as an antagonist in low-affinity states, dose dependently stimulated group A neurones, but inhibited the effect of the high doses of CCK-8 on group B neurones. Duodenal perfusion of 5-HT evoked dose-dependent increases in nodose neuronal discharges. Some neurones that responded to 5-HT showed no response to either high or low doses of CCK-8. A separate group of nodose neurones that possessed high-affinity CCK type A (CCK-A) receptors also responded to luminal infusion of 5-HT. F...Continue Reading

References

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Citations

Nov 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ying LiChung Owyang
Jun 8, 2013·Pharmacological Reports : PR·Katarzyna Nawrot-PorąbkaRussel J Reiter
Aug 14, 2009·Autonomic Neuroscience : Basic & Clinical·Michael J Beyak
Nov 26, 2008·European Journal of Pharmacology·Bashair M MussaAnthony J M Verberne
Jul 29, 2008·Brain Research Reviews·Daniela M Sartor, Anthony J M Verberne
Mar 22, 2012·British Journal of Pharmacology·Amanda J PageRichard L Young
Sep 4, 2012·Behavioural Brain Research·Xu ZhangYing Li
Aug 1, 2016·Gastroenterology·Gintautas GrabauskasChung Owyang
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David M SavastanoMihai Covasa
Jun 11, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Johannes A RomijnHanno Pijl
May 28, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ying LiChung Owyang
Aug 12, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gunnar Flemström, Markus Sjöblom
Oct 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniela M SartorAnthony J M Verberne
Feb 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R HayesMihai Covasa
Nov 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David M SavastanoMihai Covasa
Apr 30, 2017·Medicina·Gintautas Grabauskas, Chung Owyang
Sep 14, 2004·Gastroenterology·Chung Owyang, Craig D Logsdon

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