PMID: 11910257Mar 23, 2002Paper

Serotonin and fluoxetine levels in plasma and platelets after fluoxetine treatment in depressive patients

Journal of Clinical Psychopharmacology
Patrizia BlardiPaolo Castrogiovanni

Abstract

Depression is a mood disorder characterized by complex alterations of neurotransmitters such as serotonin, norepinephrine, and dopamine. In particular, there is substantial evidence of abnormalities in serotonin neurotransmission. Peripheral parameters of serotoninergic transmission, such as the 5-hydroxytryptamine content of plasma and platelets, have been used to identify biochemical alterations related to depression. In recent years, these parameters have also been used to examine the mechanism of action of antidepressive drugs such as the selective serotonin reuptake inhibitors. This study investigated the interaction between the plasma and platelet levels of fluoxetine and serotonin after fluoxetine administration to depressed patients. Twelve patients affected by major depression (according to the DSM-IV criteria) received a single oral dose of fluoxetine in the morning: 5 mg in the first 5 days, 10 mg from day 6 to day 10, and 20 mg from day 11 to day 40. Blood samples were collected at 0, 7, 10, and 24 hours after drug administration on the day 1 of fluoxetine 5 mg and on the 1st and the 30th day of fluoxetine 20 mg (days 11 and 40 of treatment, respectively). Plasma fluoxetine and serotonin levels increased after drug ...Continue Reading

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Citations

Mar 3, 2005·Neuropsychobiology·Patrizia BlardiPaolo Castrogiovanni
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Raymond G Schlienger, Christoph R Meier
Dec 1, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anteneh M FeyissaBeata Karolewicz
Dec 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Maria Eugenia HernandezLenin Pavón
Sep 23, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·María Eugenia HernándezLenin Pavón
Mar 29, 2016·Human Psychopharmacology·Aarthi ManoharanAbialbon Paul
Jun 16, 2015·Neuron·Takeshi MoritaDiana M Bautista
Jul 8, 2008·Epilepsy Research·Salvatore GrossoPaolo Balestri
Mar 21, 2017·Clinical and Experimental Pharmacology & Physiology·Sattar OstadhadiAhmad-Reza Dehpour
Jul 19, 2006·American Journal of Primatology·Erin L KinnallyJeffrey A French
May 7, 2005·Journal of Clinical Psychopharmacology·Patrizia BlardiPaolo Castrogiovanni
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mihaela PavlicevGünter P Wagner
Sep 4, 2008·Physiological Genomics·Jan A MennigenVance L Trudeau
Mar 5, 2019·Journal of Affective Disorders·Amanda HolckDaniel Lindqvist

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