Serotonin and insulin-like peptides modulate leucokinin-producing neurons that affect feeding and water homeostasis in Drosophila

The Journal of Comparative Neurology
Yiting LiuDick R Nässel

Abstract

Metabolic homeostasis and water balance is maintained by tight hormonal and neuronal regulation. In Drosophila, insulin-like peptides (DILPs) are key regulators of metabolism, and the neuropeptide leucokinin (LK) is a diuretic hormone that also modulates feeding. However, it is not known whether LK and DILPs act together to regulate feeding and water homeostasis. Because LK neurons express the insulin receptor (dInR), we tested functional links between DILP and LK signaling in feeding and water balance. Thus, we performed constitutive and conditional manipulations of activity in LK neurons and insulin-producing cells (IPCs) in adult flies and monitored food intake, responses to desiccation, and peptide expression levels. We also measured in vivo changes in LK and DILP levels in neurons in response to desiccation and drinking. Our data show that activated LK cells stimulate diuresis in vivo, and that LK and IPC signaling affect food intake in opposite directions. Overexpression of the dInR in LK neurons decreases the LK peptide levels, but only caused a subtle decrease in feeding, and had no effect on water balance. Next we demonstrated that LK neurons express the serotonin receptor 5-HT1B . Knockdown of this receptor in LK neur...Continue Reading

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Citations

Aug 4, 2015·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·S KojimaE Ito
Sep 17, 2015·PloS One·Megan E GarlapowTrudy F C Mackay
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Feb 7, 2021·International Journal of Molecular Sciences·Dick R Nässel, Shun-Fan Wu
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Mar 7, 2021·International Journal of Molecular Sciences·Dick R Nässel
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Apr 13, 2021·Frontiers in Behavioral Neuroscience·Deepthi MahishiWolf Huetteroth

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