Serotonin and stress-induced increases in renin secretion are not blocked by sympathectomy/adrenal medullectomy but are blocked by beta antagonists

Brain Research
K D MortonL D Van de Kar

Abstract

The present study examined the role of the sympathetic nervous system as a mediator of the message from the CNS to the kidneys to stimulate the secretion of renin. Two procedures that increase the secretion of renin were tested: administration of the serotonin releaser fenfluramine, which increases renin release without altering blood pressure [53], and subjecting the rats to the 'psychological' stressor of conditioned emotional response (CER) stress. Pretreatment of rats with either the beta antagonist sotalol or the beta 1-selective antagonist atenolol completely prevented the increase in plasma renin activity and concentration caused by fenfluramine (5 mg/kg i.p.) injection. However, chemical sympathectomy with 6-hydroxydopamine (6-OHDA) combined with surgical adrenal medullectomy did not prevent the increase in plasma renin activity and concentration following fenfluramine injection. Since beta-antagonists have been previously shown to prevent the renin response to CER stress, we also tested whether the sympathetic nervous system mediates the renin response to CER stress. Chemical sympathectomy combined with adrenal medullectomy did not prevent the effect of CER stress on renin release. The completeness of the sympathectomy...Continue Reading

References

Feb 1, 1976·The Journal of Clinical Investigation·M S TaherA L McCool
May 1, 1992·Neuroendocrinology·J H UrbanL D Van de Kar
Nov 22, 1991·The Journal of Comparative Neurology·R P Vertes
Jan 1, 1989·Pflügers Archiv : European journal of physiology·H EhmkeH Kirchheim
Jan 14, 1986·European Journal of Pharmacology·D N Middlemiss
Oct 7, 1985·Life Sciences·J H UrbanM S Brownfield
Sep 1, 1985·Pflügers Archiv : European journal of physiology·H R KirchheimP Persson
Jul 1, 1973·Journal of Neurochemistry·J T Coyle, D Henry
Jul 1, 1972·The Journal of Clinical Investigation·I A ReidL E Earley
Feb 1, 1973·Circulation Research·R VandongenG W Boyd
Oct 8, 1984·Brain Research·L D Van de KarC L Bethea
Apr 13, 1984·European Journal of Pharmacology·S Giarcovich, M A Enero

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Citations

Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Jul 1, 2009·Animal : an International Journal of Animal Bioscience·M A ChadwickD K Revell
Jan 12, 1999·Frontiers in Neuroendocrinology·L D Van de Kar, M L Blair
Jan 11, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Itsuro MatsumotoTadaomi Aikawa
Oct 17, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Shoko TazumiKeiko Morimoto
Jul 1, 1997·Journal of Applied Physiology·G BaoE C Fletcher
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W HuangA F Sved
Aug 13, 1999·The American Journal of Physiology·E SeeligerH W Reinhardt

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