PMID: 10821327May 23, 2000

Serotonin and the heart

Annals of Medicine
W H Frishman, P Grewall

Abstract

Serotonin is a naturally occurring vasoactive substance that has diverse cardiophysiological effects. These effects can be explained by the existence of serotonin receptor subtypes which mediate different biological actions. The vasoconstrictive actions of serotonin are mediated by 5-HT2 serotonergic receptors, and serotonin also amplifies the release and activities of other vasoconstrictors, such as angiotensin and norepinephrine. Abnormalities in the serotonergic system may play an important role in the pathophysiology of multiple cardiovascular disease states such as systemic hypertension, primary pulmonary hypertension and peripheral vascular disease. Selective 5-HT2 serotonergic receptor blockers have been developed which appear to be potent vasodilators with therapeutic potential in various cardiovascular disease states. The largest clinical experience has been collected with ketanserin, and other agents in this class are being investigated. Prolongation of the ECG QT interval with 5-HT2 serotonergic receptor blockers may pose a potential risk with these treatments in some patients.

References

Mar 1, 1992·Journal of the American College of Cardiology·L WrightR J Bache
Jan 1, 1990·Cardiovascular Drugs and Therapy·L S MalatinoG Tamburino
Jan 1, 1985·Journal of Cardiovascular Pharmacology·K GradinB Persson
Jan 1, 1985·Journal of Cardiovascular Pharmacology·M A NelsonJ A Whitworth
Jan 1, 1985·Journal of Cardiovascular Pharmacology·M Baudouin-LegrosP Meyer
Jan 1, 1985·Journal of Cardiovascular Pharmacology·R FagardA Amery
Jan 1, 1985·Journal of Cardiovascular Pharmacology·P W de Leeuw, W H Birkenhäger
Jan 1, 1985·Journal of Cardiovascular Pharmacology·J StaessenA Amery
Jan 1, 1985·Journal of Cardiovascular Pharmacology·T HednerG Berglund
Jan 1, 1985·Journal of Cardiovascular Pharmacology·H J Waal-ManningF O Simpson
Jan 1, 1985·Journal of Cardiovascular Pharmacology·L A FerraraM Mancini
Jan 1, 1985·Journal of Cardiovascular Pharmacology·L M WingJ R Graham
Jan 1, 1985·Journal of Cardiovascular Pharmacology·F ManteroD D'Agostino
Jan 1, 1985·Journal of Cardiovascular Pharmacology·P A Janssen
Jan 1, 1985·Journal of Cardiovascular Pharmacology·J ArnoutA Amery
Jan 1, 1985·Journal of Cardiovascular Pharmacology·J De CreeH Verhaegen
Jan 1, 1985·Journal of Cardiovascular Pharmacology·J H MyersR C Webb
Jan 1, 1985·Journal of Cardiovascular Pharmacology·J M Van Nueten
Jan 1, 1985·Journal of Cardiovascular Pharmacology·B Arneklo-NobinK Törnebrandt
Sep 1, 1985·Journal of Cardiovascular Pharmacology·L A FerraraS Soro
Dec 1, 1988·Clinical Pharmacology and Therapeutics·T C NaslundA J Wood
Apr 1, 1986·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P M Vanhoutte, T F Lüscher
Jul 1, 1988·American Journal of Hypertension·T Hedner, B Persson
Jan 1, 1987·European Journal of Clinical Pharmacology·A BerdeauxJ F Giudicelli
Jul 1, 1985·Postgraduate Medical Journal·H A Cameron, L E Ramsay
Mar 1, 1988·The Medical Clinics of North America·W H FrishmanS Huberfeld
Jul 1, 1988·American Journal of Hypertension·P K ZachariahS G Ritter
Feb 1, 1987·Archives of Internal Medicine·S G ShepsD C Agerter
Feb 1, 1985·Urology·V L CarpinielloA J Wein
Aug 6, 1983·British Medical Journal·I W Reimann, J C Frölich
Aug 1, 1983·British Journal of Clinical Pharmacology·T HednerG Berglund
Jan 1, 1983·European Journal of Clinical Pharmacology·B PerssonG Berglund
Feb 20, 1982·British Medical Journal·G J WentingM A Schalekamp
Aug 1, 1995·Cardiovascular Research·T FukaiA Takeshita
Jun 1, 1995·Journal of Clinical Pharmacology·W H FrishmanB Shareef
Apr 1, 1994·Circulation·K H BenzulyD D Heistad
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M FernándezJ Rodés
Jan 1, 1993·European Journal of Clinical Pharmacology·G GleerupK Winther
Apr 14, 1997·Journal of the Autonomic Nervous System·S S MeyrellesE C Vasquez
Jun 1, 1997·Journal of Cardiovascular Pharmacology·F R StassenJ G De Mey
Aug 1, 1997·Journal of Cardiovascular Pharmacology·K Chaouche-TeyaraH Dabiré
Dec 24, 1997·European Heart Journal·P M Vanhoutte
May 19, 1998·Life Sciences·O YildizR E Purdy
Jan 15, 1999·Clinical and Experimental Pharmacology & Physiology·Y MurakamiR Murakami
Mar 3, 1999·Clinical and Experimental Hypertension : CHE·N K Singh, R K Goyal
May 18, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R PakalaC R Benedict
Jun 25, 1999·Molecular Genetics and Metabolism·D E ComingsW R Peters
Aug 3, 1999·Circulation·K VikenesJ E Nordrehaug
Jul 1, 1954·Physiological Reviews·I H PAGE

Citations

Jul 3, 2007·Bulletin of Experimental Biology and Medicine·A A MustafinL M Mirolyubov
Jan 3, 2001·European Journal of Pharmacology·Jeremy Veenstra-VanderweeleEdwin H Cook
Aug 23, 2003·Journal of Psychosomatic Research·Robert PohlVikram Yeragani
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Brian J Jones, Thomas P Blackburn
Dec 1, 2001·Trends in Cardiovascular Medicine·Canan G Nebigil, Luc Maroteaux
Sep 27, 2012·Chemical Research in Toxicology·Yoji KatoAnthony J Kettle
Apr 18, 2009·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·D I NasyrovaM V Ugriumov
Jun 17, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Miyuki YamamotoJun Nakura
Feb 15, 2011·International Journal of Environmental Research and Public Health·Francine RenduJean-Marie Launay
May 7, 2011·Theranostics·Melissa MillardNouri Neamati
May 3, 2014·Biological & Pharmaceutical Bulletin·Tatsuya MutoYoshihiro Hotta
Feb 11, 2014·Autonomic Neuroscience : Basic & Clinical·Lilia S Urzedo-RodriguesJosmara Bartolomei Fregoneze
Feb 4, 2014·American Journal of Respiratory Cell and Molecular Biology·Brian D MooreEdward S Schelegle
Feb 6, 2010·Neurochemical Research·M V Ugrumov
Aug 26, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Kartik BalachandranAjit P Yoganathan
Apr 28, 2006·The Canadian Journal of Cardiology·C BourgaultPaul Poirier
Sep 8, 2010·Autonomic Neuroscience : Basic & Clinical·Lilia S Urzedo-RodriguesJosmara Bartolomei Fregoneze
Mar 25, 2008·European Journal of Pharmacology·John W AdamsDaniel T Connolly
Jul 8, 2008·British Journal of Pharmacology·A A HerbertK J Broadley
Oct 6, 2007·British Journal of Haematology·Sheritha P LeeLeslie V Parise
Jun 16, 2012·Journal of Cellular and Molecular Medicine·Keren OfekHermona Soreq
Nov 25, 2004·Journal of Biochemical and Biophysical Methods·Ulrike EderHeinz Juan
Oct 27, 2004·Pharmacology & Therapeutics·Takafumi NagatomoTadazumi Komiyama
Oct 16, 2008·Biochemical and Biophysical Research Communications·Luigi Michele PavoneLuigi Avallone
May 4, 2004·Trends in Molecular Medicine·Francine CôtéGuilan Vodjdani
Nov 3, 2004·Brain Research·Hilda Silva FerreiraJosmara Bartolomei Fregoneze
Nov 30, 2014·Molecular and Cellular Endocrinology·H LefebvreE Louiset
Jun 22, 2014·Molecular and Cellular Endocrinology·Zubova YuliaUgrumov Michael
Mar 27, 2016·QJM : Monthly Journal of the Association of Physicians·S J FenningMwj Strachan
Oct 11, 2007·The International Journal of Neuropsychopharmacology·Maria A StasiPaolo Carminati
Apr 18, 2012·Respiration; International Review of Thoracic Diseases·Brian D MooreEdward S Schelegle
Aug 5, 2004·European Journal of Human Genetics : EJHG·Lauren A WeissMark Abney
Sep 7, 2018·Psychosomatic Medicine·Stephen H BoyleAnastasia Georgiades
May 9, 2006·Developmental Neuroscience·Michael LevinJean M Lauder
Nov 8, 2007·Genesis : the Journal of Genetics and Development·Luigi Michele PavoneAntonio Baldini
Nov 11, 2005·Developmental Neuroscience·Takahiro FukumotoMichael Levin
Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Luca CarnevaliEugene Nalivaiko
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Canan G NebigilLuc Maroteaux
May 6, 2004·Physiological Genomics·Jennie E LarkinJohn Quackenbush
Mar 6, 2019·Texas Heart Institute Journal·Pradhum RamGregg S Pressman
Mar 11, 2020·Frontiers in Cellular Neuroscience·Xiali ZhongDavid Pamies
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Apostolia Maria TsimberidouRazelle Kurzrock

Related Concepts

Metazoa
Antihypertensive Agents
Arteriosclerosis
Diastolic Blood Pressure
Cardiovascular Diseases
Endothelium, Vascular
Heart
Hemodynamics
Hypertensive Disease
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