PMID: 6411504Apr 1, 1983Paper

Serotonin and the ovarian hyperstimulation syndrome

European Journal of Obstetrics, Gynecology, and Reproductive Biology
I ZaidiseE Paldi

Abstract

Ovarian hyperstimulation syndrome was induced in rabbit by administration of human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG). In an attempt to establish whether serotonin plays a part in the induction of this syndrome, the hyperstimulated rabbits were divided into two groups and were administered known anti-serotonin drugs, cyproheptadine and methysergide, respectively. The group treated with cyproheptadine, a non-specific serotonin antagonist, exhibited significant acceleration in the regression of the syndrome. Methysergide, a specific serotonin antagonist, administered to the second group, neither prevented the occurrence of the syndrome nor accelerated its regression. The results of this work indicate that serotonin does not seem to be directly involved in the production of the ovarian hyperstimulation syndrome in rabbits.

References

Sep 1, 1980·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E S LindenbaumJ Brandeis
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Bassam M TaherKamel M Ajlouni

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Citations

Oct 1, 1992·Journal of Assisted Reproduction and Genetics·P A Bergh, D Navot
Mar 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M V SauerR A Lobo
Jun 30, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M Tsirigotis, I Craft
Apr 28, 2000·Fertility and Sterility·J G Whelan, N F Vlahos
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Talha Al-Shawaf, J G Grudzinskas
Jul 15, 1998·Obstetrical & Gynecological Survey·C C BeerendonkJ M Merkus
Dec 3, 1998·The Journal of Clinical Investigation·E R LevinA Pedram
Dec 9, 2014·Reproduction, Fertility, and Development·Leopoldina ScottiFernanda Parborell
Aug 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N DoldiA Ferrari

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