Serotonin and thermoregulation. Physiologic and pharmacologic aspects of control revealed by intravenous m-CPP in normal human subjects

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
P J SchwartzD L Murphy

Abstract

Meta-chlorophenylpiperazine (m-CPP), a probe of central serotonergic function, elevates core temperature in rodents, nonhuman primates, and humans via serotonin receptor-mediated mechanisms. To further characterize the thermoregulatory aspects of this response, we studied 16 healthy volunteers using multiple core and skin temperature recording sites. Compared to placebo, intravenous m-CPP (0.08 mg/kg) produced statistically significant biphasic changes in rectal temperature, characterized by initial hypothermia (-0.04 degrees C at 12 minutes) followed by progressive hyperthermia (+0.17 degrees C at 90 minutes). m-CPP also produced significant increases in plasma norepinephrine concentrations. Analysis of the skin temperature recordings suggests that the effector mechanism primarily responsible for m-CPP-induced core hyperthermia is increased metabolic thermogenesis. Individual differences in the magnitude of the hyperthermia were independent of m-CPP plasma concentrations but were found to be linearly correlated with the level of the previous night's core rectal temperature minimum and mean. It appears that m-CPP activates a mode of metabolic thermogenesis governed by a nocturnally sensitive proportional control mechanism. The ...Continue Reading

Citations

Jun 7, 2000·Psychoneuroendocrinology·F G MoellerA C Swann
Oct 23, 1997·Critical Care Clinics·T C ChanR F Clark
Jul 14, 2006·Menopause : the Journal of the North American Menopause Society·Rebecca C ThurstonBernard L Harlow
Mar 16, 2004·Psychosomatics·David M Blass, Michelle Chuen
May 20, 2011·Journal of Medical Case Reports·Lalith Rmr RasnayakeAmitha Npk Nelumdeniya
Mar 3, 2005·Medicine and Science in Sports and Exercise·Arthur T StrachanRonald J Maughan
Mar 24, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrew C Gallup, Gordon G Gallup
Jun 14, 2008·Physiology & Behavior·Andrew C Gallup, Gordon G Gallup
Dec 10, 2009·Journal of Neuroscience Research·Hanan AhabrachMarta Llansola
May 20, 2014·Pharmacology & Therapeutics·Rae R MatsumotoJames P O'Callaghan
Jun 28, 2003·Pharmacology & Toxicology·Mohammad-Reza ZarrindastMousa Sahebgharani
May 24, 2008·The Journal of Pharmacy and Pharmacology·Daniela J ConradoTeresa Dalla Costa
Dec 3, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F NoëlC L M Silva
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Klaas P ZuideveldMeindert Danhof
Dec 14, 2019·Journal of Clinical Psychopharmacology·Ketan HiraparaRashi Aggarwal
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K P ZuideveldM Danhof
Nov 25, 2018·Biomedicines·Noof Abdullah ShaifInsop Shim
Aug 6, 2019·BioMed Research International·Noof Abdullah ShaifInsop Shim

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