PMID: 2508084Jan 1, 1989Paper

Serotonin and treatment in obsessive-compulsive disorder

Psychiatric Developments
J S MarchJ H Greist

Abstract

Recognized since the Middle Ages, and clearly described for more than 100 years, obsessive-compulsive disorder (OCD) continues to intrigue and challenge mental health professionals. Recent evidence has implicated dysfunctional serotonergic neurotransmission in OCD. This review summarizes the evidence favoring a serotonergic hypothesis for OCD followed by a more detailed discussion of the implications the hypothesis holds for treatment.

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