PMID: 6539213Mar 1, 1984Paper

Serotonin and tryptophan hydroxylase in isolated hypothalamic and brain stem nuclei of rats exposed to acute and repeated immobilization stress

Experimental and Clinical Endocrinology
J CulmanR Kvetnanský

Abstract

The effect of acute and repeated immobilization stress on serotonin concentration and tryptophan hydroxylase activity in some isolated hypothalamic and brain stem nuclei was measured using a special microdissection technique and sensitive isotopic-enzymatic microassays. In acutely immobilized rats serotonin concentration was increased in the median eminence, ventromedial and dorsomedial nuclei. In repeatedly immobilized rats increased serotonin concentration was recorded in the dorsomedial nucleus immediately after seven, and in the median eminence after forty consecutive daily exposures to immobilization. Decreased tryptophan hydroxylase activity was found in the suprachiasmatic nucleus after seven exposures to immobilization stress. Acute and repeated immobilization stress failed to produce any changes of serotonin concentration in the isolated brain stem nuclei studied, and of tryptophan hydroxylase activity in the dorsal raphe nucleus and n. centralis superior. The increased tryptophan hydroxylase activity observed without any changes in serotonin concentration in the locus coeruleus after the 7th immobilization may suggest an increased synthesis and release rate of serotonin in serotonergic nerve terminals in this area. Th...Continue Reading

Citations

Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Mar 1, 1988·Pain·Carlo A Porro, Giancarlo Carli
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M DiksicY L Yamamoto
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S E GartsideA H Young
Mar 1, 1997·The European Journal of Neuroscience·N SingewaldA Philippu
Aug 10, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A B PiekarzewskaG Sender
Jan 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S NagahiroY L Yamamoto
Jan 7, 1999·Stress : the International Journal on the Biology of Stress·L G Kirby, I Lucki

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