Serotonin augments the cationic current Ih in central neurons.

Neuron
D H Bobker, J T Williams

Abstract

Serotonin (5-HT) induced a slow depolarization when superfused onto neurons of the rat brainstem nucleus prepositus hypoglossi (PH) in vitro. The depolarization was associated with a decrease in cell input resistance. In voltage clamp, 5-HT caused an inward current that activated at approximately -50 mV and was present only at potentials negative to this. With hyperpolarizing voltage-clamp steps, PH neurons exhibited a slow inward current relaxation. The properties of this conductance were consistent with the cationic, nonselective current, Ih. Bath-applied 5-HT augmented Ih. Extracellular CsCl blocked both Ih and the inward current produced by 5-HT. In addition, forskolin, isobutylmethylxanthine, and 8-bromo-cAMP mimicked the inward current seen with 5-HT. The 5-HT1 agonist 5-carboxamidotryptamine produced a similar inward current. We conclude that 5-HT excites PH neurons by augmenting Ih, probably through receptor-mediated stimulation of adenylate cyclase. As Ih is found in many types of neurons, this mechanism may be a common mode of regulating cell excitability.

References

Jul 19, 1979·Nature·H F BrownS J Noble
Aug 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R MarksteinG Engel
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly

❮ Previous
Next ❯

Citations

Jan 1, 1997·Hippocampus·D MattiaM Avoli
Sep 1, 1995·Pflügers Archiv : European journal of physiology·P M LarkmanT Takahashi
Aug 10, 2006·Anatomy and Embryology·J LierschK Zilles
May 1, 1990·Trends in Neurosciences·D H Bobker, J T Williams
Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·N J Penington
Jan 1, 1991·Progress in Neurobiology·R W Greene, H L Haas
Sep 19, 2003·Hearing Research·Aasef G Shaikh, Paul G Finlayson
Oct 6, 1999·The European Journal of Neuroscience·S Gasparini, D DiFrancesco
Feb 13, 2003·Epilepsia·Masaomi KitayamaShinichi Kogure
Nov 28, 2013·The Journal of General Physiology·Lei HuSteven Siegelbaum
Mar 1, 1995·The European Journal of Neuroscience·N B MercuriG Bernardi
Apr 21, 2004·Cephalalgia : an International Journal of Headache·U ReuterC Waeber
Feb 3, 1999·Annals of the New York Academy of Sciences·R Andrade
Jan 4, 2013·PloS One·Cristina GambardellaOttorino Belluzzi
Jan 1, 1990·Journal of Basic and Clinical Physiology and Pharmacology·H C Pape, D A McCormick
Mar 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krzysztof PtakJeffrey C Smith
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrea SaponaroAnna Moroni
Sep 22, 2007·Neuroscience Research·Hiroshi Kuba
Sep 29, 2004·The European Journal of Neuroscience·Bernat Kocsis, Shaomin Li
Jun 15, 2007·The European Journal of Neuroscience·Sara S N HoWing-Ho Yung
Jul 1, 1994·Neuron·S L Ingram, J T Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.