Serotonin depletion attenuates cocaine seeking but enhances sucrose seeking and the effects of cocaine priming on reinstatement of cocaine seeking in rats

Psychopharmacology
L T Tran-NguyenJanet L Neisewander

Abstract

Acute serotonin (5-HT) depletion by the tryptophan hydroxylase inhibitor, para-chlorophenylalanine, attenuates cocaine seeking in rats. The present study examined the effects of chronic 5-HT depletion on cocaine- and sucrose seeking using the 5-HT-selective neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). Separate groups of rats were trained to lever press for cocaine infusions (0.33 mg/kg/0.1 ml, i.v.) or for sucrose pellets (45 mg Noyes) on a fixed ratio (FR) 1 schedule of reinforcement during daily 2-h sessions. Subsequently, animals received i.c.v. infusions of either vehicle or 5,7-DHT (150 microg/6 microl or 200 microg/20 microl). After a minimum of 10 days post-lesion, cocaine- and sucrose seeking were measured as lever presses in the absence of reinforcement (extinction). Some cocaine-trained animals were also assessed for the re-establishment of self-administration and reinstatement of extinguished cocaine seeking by i.v. cocaine priming injections and response-contingent presentations of cocaine-paired stimuli. 5-HT depletion by the 150 microg/6 microl dose of 5,7-DHT failed to alter cocaine- and sucrose seeking despite producing a 42-77% depletion of 5-HT in limbic terminal regions. The 200 microg/20 microl dose of 5,7-...Continue Reading

Citations

Nov 19, 2003·European Journal of Pharmacology·Guy A Higgins, Paul J Fletcher
Jul 16, 2013·Neuropharmacology·Kathryn A Cunningham, Noelle C Anastasio
Jun 4, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nathan S PentkowskiJanet L Neisewander
Aug 5, 2009·Addiction Biology·Nathan S PentkowskiJanet L Neisewander
Sep 18, 2007·Psychopharmacology·Geoffrey van der PlasseMatthijs G P Feenstra
Feb 5, 2013·Drug and Alcohol Dependence·Keith L SheltonPatrick M Beardsley
Nov 27, 2010·Pharmacology, Biochemistry, and Behavior·Aaron EttenbergOsnat Ben-Shahar
Jul 22, 2008·Behavioural Brain Research·Bríd A Nic Dhonnchadha, Kathryn A Cunningham
May 13, 2008·Drug and Alcohol Dependence·Susan SchenkEvangeline Daniela
May 29, 2014·British Journal of Pharmacology·B Jupp, J W Dalley
Feb 1, 2005·Pharmacology, Biochemistry, and Behavior·Jazmin I AcostaJanet L Neisewander
Sep 9, 2005·Drug and Alcohol Dependence·Shijing Liu, Kathryn A Cunningham
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Apr 7, 2011·Neuropharmacology·L G KirbyC A Winstanley
Feb 11, 2015·Psychopharmacology·Christian MontanariAldo Badiani
May 2, 2003·Psychopharmacology·David H Epstein, Kenzie L Preston
Jan 17, 2003·Psychopharmacology·Jeffrey J BurmeisterJanet L Neisewander
Jan 24, 2009·Journal of Psychopharmacology·O J RobinsonB J Sahakian
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey J BurmeisterJanet L Neisewander
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen K SzumlinskiPeter W Kalivas
Jun 19, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Debra S HarrisReese T Jones
Jul 17, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher C LedfordRonald E See
Dec 31, 2004·The American Journal of Drug and Alcohol Abuse·Debra S HarrisS Paul Berger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.