Serotonin depletion eliminates sex differences with respect to context-conditioned immobility in rat

Psychopharmacology
Robert PetterssonElias Eriksson

Abstract

Previous studies have shown that male rats display more anxiety-like behavior than females as assessed using the elevated plus maze and that serotonin depletion abolishes this difference by exerting an anxiolytic-like effect in males only. To compare male and female rats with respect to immobility and startle responses to sudden noise bursts after contextual fear conditioning and to explore to what extent any possible sex difference in this regard is influenced by serotonin depletion during testing (but not acquisition). In line with previous studies, males displayed more immobility following contextual conditioning induced by previous exposure to foot shocks than females. In males but not females, the immobility response was reduced by administration of the serotonin synthesis inhibitor para-chlorophenylalanine (PCPA) between shock exposure and testing, the consequence being that males and females no longer differed in this regard. Untreated males but not females displayed a negative correlation between fear-conditioned startle and immobility, suggesting that the latter behavior, when excessive, interferes with the former. In line with this assumption, the reduction in immobility following administration of PCPA in males coinc...Continue Reading

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Citations

Dec 17, 2017·Learning & Memory·Allison R FoilbJohn P Christianson
Apr 24, 2019·Journal of Psychopharmacology·Rebeca Machado FigueiredoThelma Anderson Lovick
Feb 18, 2021·Acta Neuropsychiatrica·S Melker HagsäterElias Eriksson
Jul 7, 2021·The International Journal of Neuropsychopharmacology·Sven Melker HagsäterElias Eriksson

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