PMID: 8599393Apr 1, 1996Paper

Serotonin-dopamine interaction and its relevance to schizophrenia

The American Journal of Psychiatry
S Kapur, G Remington

Abstract

The therapeutic success of clozapine and risperidone has focused attention on the interaction between serotonin and dopamine systems as an avenue for superior therapeutics in schizophrenia. The authors review the neurobiological basis for this interaction and its clinical relevance. The authors synthesized information from more than 100 published articles obtained through electronic and bibliography-directed searches. The serotonin system inhibits dopaminergic function at the level of the origin of the dopamine system in the midbrain as well as at the terminal dopaminergic fields in the forebrain. Serotonergic antagonists release the dopamine system from this inhibition. This disinhibition of the dopamine system in the striatum may alleviate neuroleptic-induced extrapyramidal symptoms, and a similar disinhibition in the prefrontal cortex may ameliorate negative symptoms. However, the benefits of combined serotonergic-dopaminergic blockade may be observed in only a narrow dose range and may be lost with doses that produce suprathreshold dopaminergic blockade. Serotonergic modulation of dopaminergic function provides a viable mechanism for enhancing therapeutics in schizophrenia, but much remains unclear. Future research will hav...Continue Reading

Citations

Aug 1, 1996·European Journal of Nuclear Medicine·G F Busatto
Nov 1, 1996·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·F Benazzi
Jan 1, 1997·Journal of Psychopharmacology·G F Busatto, R W Kerwin
Oct 24, 1997·The British Journal of Psychiatry : the Journal of Mental Science·M J TravisD Terriere
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·R ShilohA Weizman
Jul 8, 1998·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·R W LamS Altman
Dec 24, 1998·Journal of Clinical Psychopharmacology·F J KuoW H Chang
Apr 10, 1999·Issues in Mental Health Nursing·J H Flaskerud, A K Wuerker
May 4, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·O Blin
Jun 1, 2000·Journal of Clinical Psychopharmacology·K N ChengappaR A Zoretich
May 1, 2001·Journal of Toxicology. Clinical Toxicology·M J Burns
Jul 4, 2001·The British Journal of Psychiatry : the Journal of Mental Science·M Poyurovsky, A Weizman
Feb 16, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M T QueirozR Frussa-Filho
Aug 9, 2003·Expert Opinion on Drug Safety·Barbara R SommerBen Flores
Mar 5, 2004·Pharmacotherapy·Tami R ArgoPaul J Perry
May 26, 2004·Journal of Geriatric Psychiatry and Neurology·Kenichi MeguroMasatoshi Itoh
Aug 2, 2005·Arquivos de neuro-psiquiatria·Quirino Cordeiro, Homero Vallada
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philippe PichatBernard Scatton
Jun 8, 2006·The Australian and New Zealand Journal of Psychiatry·Pushpal DesarkarVinod Kumar Sinha
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kirsty E ScholesPradeep J Nathan
Feb 6, 2008·PLoS Computational Biology·Peter Dayan, Quentin J M Huys
Mar 12, 2008·Psychopharmacology·Marco BortolatoRoberto Stancampiano
Mar 1, 2008·Journal of Psychopharmacology·Zafiris J DaskalakisRobert Chen
Oct 22, 2008·Journal of Clinical and Experimental Neuropsychology·Espen WalderhaugAndres Magnusson
Mar 16, 2012·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kenichi MeguroKyoko Akanuma
Oct 12, 2012·Archives of Pharmacal Research·Ji Who KimDong Soo Lee
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alan AnticevicPhilip R Corlett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.