Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertension

Hypertension
Stephanie W Watts

Abstract

Large arteries from hypertensive subjects are hyperresponsiveness to 5-hydroxytryptamine (5-HT). We tested the hypothesis that small arteries (225 micro ID) have a profile similar to conduit arteries, including signal transduction mechanisms and the 5-HT receptor subtype(s) mediating arterial contraction in normal and high blood pressure. Aorta and mesenteric arteries from Sprague-Dawley (232+/-6 micro ID), sham (229+/-7 micro ID; systolic blood pressure, 120+/-2 mm Hg), or deoxycorticosterone acetate (DOCA)-salt rats (255+/-11 micro ID, 192+/-8 mm Hg) were mounted in a wire-based myograph. In resistance arteries from Sprague-Dawley rats, the 5-HT2A receptor mediated contraction; agonists of the 5-HT1B, 5-HT1D, 5-HT1F, and 5-HT2B receptor were inactive. The tyrosine kinase inhibitor genistein (5 micromol/L, 4.8-fold rightward shift), PD 098,059 (10 micromol/L, 3.2-fold shift), phospholipase C inhibitor NCDC (100 micromol/L), and nifedipine (50 nmol/L) reduced maximum 5-HT-induced contraction in small arteries (4.5% and 53% control, respectively). As in aorta, 5-HT had a decrease in threshold (100-fold lower), increase in potency (11.6-fold leftward shift), and increase in efficacy (140% sham response) in small arteries from DOC...Continue Reading

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Citations

Mar 9, 2011·Journal of Cardiovascular Pharmacology·Rabelais Tatchum-TalomDouglas S Martin
Jun 30, 2007·Clinical and Experimental Pharmacology & Physiology·Fu-Ming ShenDing-Feng Su
Apr 10, 2010·The Journal of Pharmacology and Experimental Therapeutics·A Elizabeth LinderStephanie W Watts
Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Jul 7, 2007·Circulation Research·Yana AnfinogenovaDale D Tang
Jun 17, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Miyuki YamamotoJun Nakura
Jul 19, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takayuki MatsumotoTsuneo Kobayashi
Aug 28, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Young Min BaeSung Il Cho
Mar 5, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Adriana GeorgescuDoina Popov
May 11, 2007·Expert Review of Cardiovascular Therapy·Glaucia CalleraRhian M Touyz
May 2, 2003·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Mar 30, 2016·Pharmacology Research & Perspectives·Emilie M OutzenMajid Sheykhzade
Jan 25, 2013·Experimental Diabetes Research·Peter M NelsonKathryn G Lamping
May 14, 2016·Pflügers Archiv : European journal of physiology·Shun WatanabeTsuneo Kobayashi
Feb 23, 2018·Journal of Animal Science·Miriam A SniderJames L Klotz
Jul 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Kevin OgdenStephanie W Watts
Jan 31, 2004·The Journal of Pharmacology and Experimental Therapeutics·Wei NiStephanie W Watts
Aug 3, 2007·The Journal of Pharmacology and Experimental Therapeutics·A Elizabeth LinderStephanie W Watts
Sep 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Connie J MarkKathleen M Eyster
Nov 27, 2018·Journal of Animal Science·Ronald J TrottaJames L Klotz
Nov 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Christopher A FooteLuis A Martinez-Lemus

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