PMID: 2119243Jul 30, 1990Paper

Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C

Brain Research
G K Aghajanian

Abstract

The 5-HT-induced inward current in rat facial motoneurons was rendered irreversible by intracellular GTP gamma S, an hydrolysis-resistant analog of guanosine 5'-triphosphate which sustains G protein activation. Conversely, the 5-HT response was reduced by GDP beta S, an analog of guanosine 5'-diphosphate which interferes with G protein activation. Inhibitors of protein kinase C enhanced the 5-HT-induced inward current. Thus, the slow inward current induced by 5-HT in facial motoneurons appears to be mediated by G proteins but modulated negatively by protein kinase C.

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Citations

Jan 12, 2011·Sleep & Breathing = Schlaf & Atmung·Stephane BesnardChristian Gestreau
Jul 20, 1993·European Journal of Pharmacology·S Rahman, R S Neuman
Dec 1, 1995·Progress in Neurobiology·J G McLarnon
Mar 10, 2000·European Journal of Pharmacology·D BurleighD Perrett
Oct 1, 1998·Neuroscience Letters·M S LeDouxL E Mays
Aug 22, 2000·Equine Veterinary Journal·H BenbarekD Serteyn
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman

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