PMID: 9225284Apr 1, 1997

Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells

Neuropharmacology
G K Aghajanian, G J Marek

Abstract

By intracellular and whole cell recording in rat brain slices, it was found that bath-applied serotonin (5-HT) produces an increase in the frequency and amplitude of spontaneous excitatory postsynaptic potentials/currents (EPSPs/EPSCs) in layer V pyramidal cells of neocortex and transitional cortex (e.g. medial prefrontal, cigulate and frontoparietal). The EPSCs were suppressed by LY293558, an antagonist selective for the AMPA subtype of excitatory amino acid receptor, and by two selective 5-HT2A receptor antagonists, MDL 100907 and SR 46349B. In addition, the EPSCs were suppressed by the fast sodium channel blocker tetrodotoxin (TTX) and were dependent upon external calcium. However, despite being TTX-sensitive and calcium dependent, there was no evidence that the EPSPs resulted from an increase in impulse flow in excitatory neuronal afferents to layer V pyramidal cells. The EPSCs could be induced rapidly by the microiontophoresis of 5-HT directly to "hot spots" within the apical (but not basilar) dendritic field of recorded neurons, indicating that excitatory amino acids may be released by a TTX-sensitive focal action of 5-HT on a subset of glutamatergic terminals in this region. Consistent with such a presynaptic action, the...Continue Reading

References

Jun 24, 1999·The Journal of Comparative Neurology·V Cornea-HébertL Descarries
Jul 8, 2005·Psychopharmacology·Christopher J MacDonald, Warren H Meck
Sep 18, 2007·Psychopharmacology·Olivia L CarterFranz X Vollenweider
Apr 15, 2008·Psychopharmacology·Masanori NagamineSoichiro Nomura
May 29, 2009·Psychopharmacology·P R CorlettP C Fletcher
Dec 15, 2010·Psychopharmacology·Adam L HalberstadtSusan B Powell
Sep 15, 2010·Pflügers Archiv : European journal of physiology·José A Troca-Marín, Emilio Geijo-Barrientos
Nov 15, 2011·Molecular Neurobiology·M Victoria Puig, Allan T Gulledge
Jun 28, 2012·The Journal of Physiological Sciences : JPS·Morteza ZendehdelElham Amini
Mar 17, 2004·Current Opinion in Pharmacology·G J Marek
Feb 6, 2004·Pharmacology & Therapeutics·David E Nichols
May 3, 2003·Neuropharmacology·A L CoppellT S C Zetterström
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·J C GewirtzG J Marek
Jul 16, 2002·Pharmacology, Biochemistry, and Behavior·Aleksandra KłodzinskaAndrzej Pilc
Nov 9, 2002·Brain Research. Brain Research Reviews·Albert AdellFrancesc Artigas
Mar 17, 2000·Brain Research. Brain Research Reviews·G K Aghajanian, G J Marek
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·T KurokiN Tashiro

Citations

Dec 1, 1989·Journal of Neuroscience Methods·M G BlantonA R Kriegstein
Jan 16, 1995·The Journal of Comparative Neurology·D E WrightL Jennes
Dec 15, 1994·The Journal of Physiology·P Piguet, M Galvan
Jun 1, 1996·Trends in Neurosciences·J Sánchez-PrietoD G Nicholls
Jan 1, 1996·Annual Review of Physiology·W E Crill
Nov 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K RasmussenG K Aghajanian

Related Concepts

Calcium [EPC]
Excitatory Amino Acid Receptor
Receptor, Serotonin,5-HT2A
Pyotraumatic Dermatitis
Cortex Bone Disorders
Adrenal Cortex Diseases
Calcium
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Serotonin Measurement
HTR2A wt Allele

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.