Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
J VargasJ Perez-Orive

Abstract

Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing restriction, so it is important to clarify these divergent findings in order to understand the direct scope and side effects of potential pharmacological treatments. We evaluated the effect of serotonin on the extent of neuritic outgrowth and morphology of three different neuronal types in the leech Haementeria officinalis during their regeneration in vitro: Retzius interneurons (Rz), annulus erector (AE) motoneurons, and anterolateral number 1 (AL1) CNS neurons. Neurons were isolated and cultured in L15 medium, with or without serotonin. Growth parameters were registered and quantified, and observed differences were analyzed. The addition of serotonin was found to induce AL1 neurons to increase their average growth dramatically by 8.3-fold (P=0.02; n=5), and to have no clear effect on AE motoneurons (P=0.44; n=5). For Rz interneurons, which normally do not regenerate their neur...Continue Reading

References

Oct 29, 1982·Science·E R Kandel, J H Schwartz
Jul 20, 2002·Science·Javier Perez-OriveGilles Laurent
Feb 4, 2003·The Journal of Physiology·Citlali TruetaFrancisco F De-Miguel
Sep 30, 2003·Reviews in the Neurosciences·Ronald E van Kesteren, Gaynor E Spencer
Jul 29, 2005·Cellular and Molecular Neurobiology·Francisco F De-Miguel, Citlali Trueta
Nov 2, 2005·Progress in Neurobiology·William B KristanW Otto Friesen
Dec 7, 2005·The Journal of Cell Biology·Giovanna Lalli, Alan Hall
Oct 16, 2007·BioTechniques·Tony J Collins
Jul 28, 2009·Annual Review of Medicine·Miles BergerBryan L Roth
Jun 22, 2010·The European Journal of Neuroscience·Tiago A FerreiraCornelius T Gross
Mar 1, 2012·Frontiers in Physiology·Francisco F De-Miguel, Kjell Fuxe
Sep 3, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepika SuriMark S Ansorge
Dec 3, 2014·Glia·Konstantin GlebovJochen Walter
May 27, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Francisco F De-MiguelBruno Mendez
Nov 6, 2015·The Journal of Experimental Biology·Daniel A Wagenaar
May 20, 2017·Nature Communications·Africa CoutoMarios Georgiou

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

ImageJ
Sigma Plot
NeuronGrowth

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.