Serotonin induces vasoconstriction of smooth muscle cell-rich neointima through 5-hydroxytryptamine2A receptor in rabbit femoral arteries

Journal of Thrombosis and Haemostasis : JTH
K NishihiraY Asada

Abstract

Smooth muscle cell (SMC)-rich intima is a morphological feature of atherosclerotic lesions that is observed in eroded plaque and spastic arteries. Arteries with SMC-rich intima are susceptible to vasoconstriction or vasospasm against some vasoactive agents. The present study evaluates the contribution of SMC-rich intima to thrombogenic vasoconstriction. We established SMC-rich neointima by damaging rabbit femoral arteries using balloons and then measured the isometric tension of the femoral strips against 5-hydroxytryptamine (5-HT), adenosine diphosphate, adenosine triphosphate and thrombin. Among these agents, only 5-HT induced a hypercontractile response of the injured arteries with SMC-rich neointima, compared with non-injured arteries. Smooth muscle cells of both the neointima and media expressed 5-HT(2A) receptor, and sarpogrelate, a selective 5-HT(2A) receptor antagonist significantly inhibited the hypercontraction. Furthermore, 5-HT induced contraction of separated neointima and hypercontraction of separated media compared with non-injured media. Sarpogrelate and fasudil, a specific Rho-kinase inhibitor, significantly suppressed such contraction of both the neointima and media of injured arteries. These results suggest t...Continue Reading

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Citations

Aug 8, 2013·Journal of Cardiovascular Pharmacology·Jianjian Shi, Lei Wei
Jan 22, 2011·Journal of Biomedicine & Biotechnology·Atsushi Yamashita, Yujiro Asada
Sep 2, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Naoko Tanaka
Aug 13, 2011·The Journal of Veterinary Medical Science·Takaharu ItamiKazuto Yamashita
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Oct 2, 2020·Biological & Pharmaceutical Bulletin·Naoko Tanaka-TotoribeRyuichi Yamamoto

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