Serotonin inhibits outgrowth of goldfish retina and impairs the trophic effect of taurine

Journal of Neuroscience Research
L LimaM Urbina

Abstract

The regeneration of explants prepared from goldfish retinas with a prior crush of the optic nerve is stimulated by the sulphur amino acid, taurine. Serotonin has been reported to modify survival, proliferation, and outgrowth of nervous tissue. In the present work we evaluated the effect of serotonin and some serotonergic agonists on the neuritic outgrowth from goldfish retinal explants. Serotonin, its precursor, 5-hydroxytryptophan, and the 5HT1A receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone, inhibited the outgrowth. The blockers of serotonin uptake, imipramine and citalopram, were also inhibitors of neurite sprouting. Imipramine favoured the inhibitory effect of serotonin at 10 days in culture. The concentration of serotonin and its metabolite, 5-hydroxyindoleacetic acid, decreased in the retina at 3 and 5 days after the crush of the optic nerve. Serotonin levels started to recover after 5 days post-lesion, and the metabolite also increased. This indicates that the lesion increases the turnover rate of serotonin and this may be related to its role in regeneration. Serotonin concentration was elevated by the intraocular administration of its precursor, 5-hydroxytryptophan, indicating that the capacity ...Continue Reading

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Citations

Dec 24, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P MatusL Lima
Oct 29, 2009·Arthropod Structure & Development·Silke Krüger, Reinhard Lakes-Harlan
Jun 30, 2011·Developmental Neurobiology·Li-Jen Lee, Lukas Jyuhn-Hsiarn Lee
May 1, 2015·Experimental Eye Research·María Eugenia Cornide-PetronioMaría Celina Rodicio
Mar 26, 2016·Progress in Neurobiology·Alexander WirthEvgeni Ponimaskin
Mar 30, 2002·The Journal of Biological Chemistry·Evgeni G PonimaskinTatyana A Voyno-Yasenetskaya
Mar 21, 2018·Neural Regeneration Research·Daniel Sobrido-CameánAntón Barreiro-Iglesias
Feb 3, 2019·Disease Models & Mechanisms·Daniel Sobrido-CameánAntón Barreiro-Iglesias

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