PMID: 2498071May 1, 1989Paper

Serotonin mediates suppression of focal epileptiform activity induced by noxious stimulation

Epilepsia
R S Neuman, P M Thompson

Abstract

Noxious stimulation can suppress epileptic seizures in humans and epileptiform activity in laboratory animals. Using as a model system the focal epileptiform activity (FEA) induced by the pneumophoresis of penicillin, the role of 5-hydroxytryptamine (5HT) in suppression of this activity by noxious stimulation was investigated. Drugs known to depress dorsal raphe unit activity, (+/-)-8-hydroxydipropylaminotetralin (DPAT), imipramine, and fluoxetine prevented suppression of FEA induced by noxious stimulation. Desimipramine, which depresses locus ceruleus but not dorsal raphe unit activity, was ineffective in blocking the suppression. Quipazine, an agonist at 5-HT receptors, in part restored the suppression that had been blocked by DPAT or imipramine. Several serotonin antagonists effective at 5-HT1 and 5-HT2 receptors blocked suppression, but an unequivocal determination of the serotonin receptor subtype mediating suppression could not be made. We conclude that 5-HT mediates suppression of FEA induced by noxious stimulation.

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Citations

Jan 1, 1994·Brain Research Bulletin·H C Dringenberg, C H Vanderwolf
Jun 1, 1992·Epilepsy Research·R GuieuG Serratrice
May 14, 1998·Neuroscience and Biobehavioral Reviews·H C Dringenberg, C H Vanderwolf
Mar 21, 2002·Epilepsia·Ulrich Ebert
Aug 16, 2003·Epilepsia·Bernhard Schaller, Stephan J Rüegg
Jan 21, 1993·The New England Journal of Medicine·E H ReynoldsD Chadwick
Nov 1, 1995·Epilepsia·J A Wada, H Tsuchimochi
Jun 24, 1998·Epilepsia·P Kotagal, G S Arunkumar
Nov 16, 2013·Experimental Brain Research·Mohammad Hadi GharedaghiReza Rahimian
Mar 21, 2007·Clinical Endocrinology·Doddabele DeepakIan A MacFarlane

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