PMID: 9533605Apr 9, 1998Paper

Serotonin metabolism in cluster headache

Cephalalgia : an International Journal of Headache
G D'AndreaG C Manzoni

Abstract

Despite some evidence of the involvement of the serotonergic system in cluster headache (CH) pathophysiology, the serotonin (5HT) metabolism has so far been poorly studied. The aim of this study was to investigate plasma and platelet levels of 5HT and 5-hydroxyindoleacetic acid (5HIAA) in CH patients in the active period of the disease. Nineteen CH sufferers and 17 sex- and age-matched healthy controls were studied. CH patients showed significantly higher plasma levels of 5HT and 5HIAA compared to controls (5HT: 5.7+/-6.1 ng/ml vs 0.2+/-0.2 ng/ml; p=0.02; 5HIAA: 34.7+/-46.1 ng/ml vs 0.6+/-0.7 ng/ml; p=0.004). In platelet 5HT levels were slightly reduced in CH patients in comparison with those of control subjects (662.4+/-522.3 ng/10(-8) platelets vs 832.4+/-587.9 ng/10(-8) platelets; n.s.) and 5HIAA levels resulted significantly lower in CH sufferers than in control subjects (3.2+/-2.6 ng/10(-8) platelets vs 6.7+/-4.8 ng/10(-8) platelets; p=0.04). Our data suggest that CH is characterized by an increase of plasma serotonergic metabolism that could reflect an involvement of the central serotonergic system in the pathogenesis of CH.

References

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Citations

Jan 20, 2005·European Journal of Clinical Pharmacology·Anna FerrariEmilio Sternieri
Apr 13, 2010·The Journal of Headache and Pain·A AutretUNKNOWN West Migraine Study Group
May 8, 2008·Current Neurology and Neuroscience Reports·Joel R Saper
Mar 17, 2001·Current Pain and Headache Reports·R Hering-Hanit, N Gadoth
Jan 29, 2011·Current Pain and Headache Reports·Giorgio Lambru, Manjit Matharu
Feb 13, 2001·Cephalalgia : an International Journal of Headache·D W DodickS D Silberstein
Sep 13, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M PeñarrochaF J Silvestre
Mar 3, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G D'AndreaA Leon
May 21, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G D'AndreaA Leon

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