Abstract
Neonatal rats were exposed to 20 or 30 min of total or partial oxygen deprivation. During asphyxia and subsequent recovery the endogenous levels of tryptophan and 5-hydroxytryptamine (5-HT, serotonin) were measured. The activity of tryptophan hydroxylase, the first and rate limiting enzyme in the 5-HT synthesis pathway, was studied in vivo by measuring the accumulation of 5-hydroxytryptophan (5-HTP) after inhibition of aromatic L-amino acid decarboxylase with NSD 1015. During asphyxia there was a decrease in tryptophan hydroxylase activity in the whole brain and various regions studied. The levels of tryptophan, 5-HTP and 5-HT all increased after 30 min of recovery from asphyxia. In the whole brain, 5-HTP and 5-HT levels were normal 2 h after anoxia while tryptophan levels normalized more slowly to reach control values after 6 h. In the regional brain study, the 5-HTP levels returned quickly to control levels after asphyxia in the striatum and midbrain but not in the brainstem and hemispheres regions. The whole brain 5-HTP and 5-HT levels did not differ from controls 24 to 48 h after the asphyxia. Although the neonatal nervous system exhibits a great resistance to asphyxia, the metabolism of the neurotransmitter 5-HT is affecte...Continue Reading
References
Jan 1, 1977·Biology of the Neonate·T HednerJ Engel
Jan 1, 1977·Biology of the Neonate·T HednerJ Engel
Jan 1, 1978·Biology of the Neonate·T HednerJ Engel
Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·A Carlsson, M Lindqvist
May 1, 1979·Pharmacology, Biochemistry, and Behavior·T HednerJ Engel
Jun 1, 1973·The Journal of Pharmacy and Pharmacology·A Carlsson, M Lindqvist
Oct 1, 1973·Journal of Neurochemistry·J N Davis, A Carlsson
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·P BédardM Lindqvist
Sep 8, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·C Atack, M Lindqvist
Jan 3, 1969·Science·M Jouvet
Aug 1, 1970·The Journal of Pharmacy and Pharmacology·C V Atack, T Magnusson
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·A CarlssonC V Atack
Aug 1, 1974·Journal of Neurochemistry·S BourgoinM Hamon
May 26, 1972·Brain Research·L A Loizou
Jan 1, 1972·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·L Olson, A Seiger
Mar 1, 1972·Journal of Neurochemistry·T Deguchi, J Barchas
Dec 1, 1971·Journal of Neurochemistry·M J Schmidt, E Sanders-Bush
Jan 1, 1968·Pharmacology·W D ReidB B Brodie
Nov 1, 1965·Journal of Neurochemistry·D S Bennett, N J Giarman
Jan 1, 1964·Acta Physiologica Scandinavica. Supplementum·A BERTLERC OWMAN
Citations
Jan 1, 1983·Journal of Neural Transmission·T Hedner, P Lundborg
Aug 1, 1985·Pharmacology, Biochemistry, and Behavior·T HednerP Lundborg
Mar 1, 1982·Neuroscience·M K Shellenberger
Jan 1, 1993·Brain Research Bulletin·M E Dell'AnnaL Olson
Aug 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C S KimE E Lawson
Dec 1, 1989·Acta Paediatrica Japonica; Overseas Edition·S TakaragiK Yamada
May 1, 1983·Acta Physiologica Scandinavica·K IversenP Lundborg
Mar 29, 2011·Journal of Neuroscience Methods·S H TakadaM I Nogueira
May 6, 2008·Brain Research·Mika ShiraishiMasayuki Itoh
Jul 1, 1986·Pediatric Pulmonology·R D BruceJ S Althaus
Jul 1, 1982·Journal of Neurochemistry·T Hedner, P Lundborg
May 1, 1996·Progress in Neurobiology·C NyakasP G Luiten
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár